IGE ISOFORMS IN FOOD INDUCED ATOPIC DERMATITIS IN CHILDREN

食物引起的儿童特应性皮炎中的 IGE 同工酶

• 批准号: 6304208
• 负责人: ANDY H LIU
• 金额: $ 3.22万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6304208
• 关键词: B lymphocyte; atopic dermatitis; blood chemistry; cell differentiation; child (0-11); clinical research; cytokine; food hypersensitivity; human subject; immunoglobulin E; lectin; peanuts; protein isoforms

In the past year, blood donations from additional study subjects have been obtained as part of this GCRC protocol to better understand the IgE-mediated mechanisms of food allergies and, in particular, of food-induced atopic dermatitis. As part of our investigation, we became particularly interested in the role that a peanut lectin glycoprotein, peanut agglutin (PNA), may help in the development of food allergies such as peanut allergy. We have been able to define specific conditions that upregulate PNA binding by lymphocytes, and we are currently refining our understanding of the conditions under which PNA induces pro-allergic cytokine secretion and/or IgE synthesis. An abstract of this work was presented at the 1999 AAAAI Annual Meeting.

在过去的一年里，作为 GCRC 方案的一部分，我们获得了更多研究对象的献血，以更好地了解 IgE 介导的食物过敏机制，特别是食物引起的特应性皮炎。作为我们研究的一部分，我们对花生凝集素糖蛋白、花生凝集素 (PNA) 可能有助于形成花生过敏等食物过敏的作用特别感兴趣。 我们已经能够确定上调淋巴细胞与 PNA 结合的特定条件，并且目前正在完善对 PNA 诱导促过敏细胞因子分泌和/或 IgE 合成的条件的理解。这项工作的摘要已在 1999 年 AAAAI 年会上发表。