EFFECT OF GENDER ON SUBSTRATE UTILIZATION DURING SUBMAXIMAL EXERCISE

性别对次极量运动期间基质利用的影响

• 批准号: 6115180
• 负责人: ANDREW R COGGAN
• 金额: $ 3.42万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6115180
• 关键词: calorimetry; carbohydrate metabolism; catecholamines; chemical kinetics; clinical research; exercise; free fatty acids; gender difference; glucose; glycerol; hormone regulation /control mechanism; human subject; insulin; lipid metabolism; oxidation; physiologic stressor; radiotracer; stable isotope

The increase in studies focusing on aberrant metabolic conditions, i.e., diabetes, and those conditions which may cause metabolic alterations away from what has been described as normal, i.e., aging, necessitates the careful examination of gender differences in substrate utilization and hormone response to metabolic stress. It is therefore, the intent of this project to examine the gender differences in carbohydrate and lipid utilization during a prolonged submaximal exercise paradigm. Stable-isotopic tracers for glucose, free fatty acids, and glycerol will be used to determine substrate kinetics. In addition, substrate oxidation will be calculated from indirect calorimetry. Measurements of catecholamines, as well as insulin, will help to provide insight into any gender differences in substrate profiles which may develop during exercise. The findings from this project will add to the greater understanding of gender specific rresponse to metabolic perturbation, and provide information to serve as a basis for using women in metabolic studies.

越来越多的研究集中在异常代谢条件，如糖尿病，以及那些可能导致代谢改变的条件，如衰老，这就需要仔细检查底物利用和激素对代谢应激反应的性别差异。因此，本项目的目的是研究在长时间亚极限运动范式中碳水化合物和脂质利用的性别差异。葡萄糖、游离脂肪酸和甘油的稳定同位素示踪剂将用于测定底物动力学。此外，底物氧化将通过间接量热法计算。儿茶酚胺和胰岛素的测量将有助于深入了解运动过程中可能产生的底物特征的性别差异。该项目的研究结果将进一步加深对代谢扰动的性别特异性反应的理解，并为利用妇女进行代谢研究提供信息基础。