EFFECT OF GENDER ON SUBSTRATE UTILIZATION DURING SUBMAXIMAL EXERCISE

关注异常代谢条件的研究增加，即， 糖尿病，以及那些可能导致代谢改变的疾病 从已经被描述为正常的情况，即衰老，需要 仔细检查底物利用率和性别差异 荷尔蒙对新陈代谢压力的反应。因此，这样做的目的是 研究碳水化合物和脂肪性别差异的项目 在延长的次极量运动范例中的利用。稳定- 将使用葡萄糖、游离脂肪酸和甘油的同位素示踪剂。 测定底物动力学。此外，基材的氧化还将进行 通过间接量热法计算得出。儿茶酚胺的测量，如 以及胰岛素，将有助于洞察任何性别差异 在运动过程中可能形成的底物分布。调查结果 这个项目将增加对性别特定的更好的理解 对代谢扰动的反应，并提供信息作为 在新陈代谢研究中使用女性的基础。

The increase in studies focusing on aberrant metabolic conditions, i.e., diabetes, and those conditions which may cause metabolic alterations away from what has been described as normal, i.e., aging, necessitates the careful examination of gender differences in substrate utilization and hormone response to metabolic stress. It is therefore, the intent of this project to examine the gender differences in carbohydrate and lipid utilization during a prolonged submaximal exercise paradigm. Stable- isotopic tracers for glucose, free fatty acids, and glycerol will be used to determine substrate kinetics. In addition, substrate oxidation will be calculated from indirect calorimetry. Measurements of catecholamines, as well as insulin, will help to provide insight into any gender differences in substrate profiles which may develop during exercise. The findings from this project will add to the greater understanding of gender specific response to metabolic perturbation, and provide information to serve as a basis for using women in metabolic studies.