EFFECT OF GENDER ON SUBSTRATE UTILIZATION DURING SUBMAXIMAL EXERCISE

性别对次极量运动期间基质利用的影响

• 批准号: 6276415
• 负责人: ANDREW R COGGAN
• 金额: $ 2.69万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6276415
• 关键词: calorimetry; carbohydrate metabolism; catecholamines; chemical kinetics; clinical research; exercise; free fatty acids; gender difference; glucose; glycerol; hormone regulation /control mechanism; human subject; insulin; lipid metabolism; oxidation; physiologic stressor; radiotracer; stable isotope

The increase in studies focusing on aberrant metabolic conditions, i.e., diabetes, and those conditions which may cause metabolic alterations away from what has been described as normal, i.e., aging, necessitates the careful examination of gender differences in substrate utilization and hormone response to metabolic stress. It is therefore, the intent of this project to examine the gender differences in carbohydrate and lipid utilization during a prolonged submaximal exercise paradigm. Stable- isotopic tracers for glucose, free fatty acids, and glycerol will be used to determine substrate kinetics. In addition, substrate oxidation will be calculated from indirect calorimetry. Measurements of catecholamines, as well as insulin, will help to provide insight into any gender differences in substrate profiles which may develop during exercise. The findings from this project will add to the greater understanding of gender specific response to metabolic perturbation, and provide information to serve as a basis for using women in metabolic studies.

关注异常代谢状况的研究增加，即， 糖尿病，以及那些可能导致代谢改变的疾病 从已经被描述为正常的，即，老化，需要 仔细检查底物利用率的性别差异， 激素对代谢应激的反应。 因此，这是一个意图， 研究碳水化合物和脂质的性别差异的项目 在长时间的次极量运动模式下的利用率。 很稳定- 将使用葡萄糖、游离脂肪酸和甘油的同位素示踪剂 以确定底物动力学。 此外，衬底氧化将是 根据间接量热法计算。 测量儿茶酚胺，如 以及胰岛素，将有助于深入了解任何性别差异 在运动过程中可能形成的基质轮廓中。 这些发现 这一项目将有助于更好地了解性别问题， 响应代谢扰动，并提供信息，作为一个 在代谢研究中使用女性的基础。