Dietary Nitrate and Muscle Power with Aging
Dietary Nitrate and Muscle Power with Aging
批准号:
9764237
负责人:
ANDREW R COGGAN
金额:
$19.69万
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
已结题
起止时间:
2018-08-15 至 2021-06-30
关键词:
AccelerometerActivities of Daily LivingAcuteAddressAgeAgingAnaerobic BacteriaArginineBiological AvailabilityBiological MarkersBiopsyCarcinogensChronicConsumptionCrossover DesignCyclic GMPDataDevelopmentDietDietary SupplementationDoseDouble-Blind MethodDropsElderlyEnzyme-Linked Immunosorbent AssayExtensorFatigueHeart failureHigh Pressure Liquid ChromatographyImpairmentIndividualIngestionInstitutionalizationIntakeIsoenzymesIsotonic ExerciseJuiceKneeLeadLifeLinkMeasuresMediatingMetabolicMetabolismMulticenter TrialsMuscleMuscle functionNADPNOS1 geneNitratesNitric OxideNitric Oxide SynthaseNitric Oxide Synthase Type INitritesOral cavityPathway interactionsPatientsPerformancePhysical FunctionPhysical activityPlacebosPlasmaPlayProductionPropertyPublic HealthPublishingQuestionnairesRandomizedResearch Project GrantsRestRoleSignal TransductionSignaling MoleculeSkeletal MuscleSoluble Guanylate CyclaseSourceSpeedSupplementationSystemTestingTimeTissuesWomanage relatedage-related muscle lossbasedeoxyhemoglobindietary nitratedisabilityinterstitialmenmiddle agemortalityolder menolder womenpleiotropism
中文摘要
项目总结
英文摘要
PROJECT SUMMARY
Muscular strength, speed, and power decrease with aging, with such changes being highly predictive of disability,
institutionalization, and mortality in the elderly. One factor potentially contributing to this impairment of muscle
function with age is an age-related decrease in nitric oxide (NO) production. NO is a key cellular signaling
molecule in many tissues, including muscle, where among other effects it influences contractile properties. With
aging, however, there is a drop in NO synthase activity and hence in NO bioavailability within muscle, as
evidenced, e.g., by a decline in the concentration of its “downstream” metabolites, i.e., nitrite (NO2-) and nitrate
(NO3-). We therefore hypothesize that dietary supplementation with NO3-, which can be non-enzymatically
reduced to form NO, will increase muscle speed and power in older persons. To test this hypotheses, a
randomized, placebo-controlled, crossover design will be used to test 20 men and women 65-79 y of age
ingesting a concentrated beetroot juice (BRJ) supplement either containing or depleted of 11.2 mmol of NO3-
(i.e., BRJ w/ NO3- or BRJ w/o NO3-). The acute (i.e., 1 d) effects of BRJ w/ or w/o NO3- on muscular speed and
power will be determined using isokinetic dynamometry. The latter tests will be repeated after chronic (i.e., 14 d)
dietary supplementation with BRJ w/ or w/o NO3-, during which time physical activity will be measured using
accelerometry and perceived fatigue and physical function during daily life will be assessed via questionnaire.
Both acutely and chronically, plasma and muscle NO3- and NO2- concentrations will be determined using high
performance liquid chromatography, breath NO levels (a biomarker for whole-body NO production) will be
measured using an electrochemical analyzer, and muscle cyclic GMP concentrations will be quantified via ELISA
so that any dietary-NO3--induced changes in muscle function can be mechanistically-linked to these parameters.
This proof-of-concept study will lead to broader, randomized, multi-center trial studies that will examine the wider
applicability of this dietary treatment in older persons. This study will also lead to deeper studies into the
mechanisms of action of NO derived from dietary NO3- in older individuals. The potential impact on public health
of finding that dietary NO3- significantly enhances muscle speed and power in older individuals is enormous.
期刊论文(3)
专著(0)
科研奖励(0)
会议论文
DOI:
10.1016/j.conctc.2020.100693
发表时间:
2021-03
期刊:
Contemporary clinical trials communications
影响因子:
1.5
作者:
[Baranauskas MN, Altherr CA, Gruber AH, Coggan AR, Raglin JS, Gupta SK, Carter SJ]
通讯作者:
Carter SJ
Dietary Nitrate Supplementation and Exercise-Related Performance.
硝酸饮食补充和与运动有关的表现。
DOI:
10.1097/nt.0000000000000431
发表时间:
2020-09
期刊:
Nutrition today
影响因子:
--
作者:
[Baranauskas MN, Coggan AR, Gruber AH, Altherr CA, Raglin JS, Carter SJ]
通讯作者:
Carter SJ
Dietary Nitrate and Muscle Function in Humans: Acute versus Chronic Mechanisms.
膳食硝酸盐和人类肌肉功能:急性与慢性机制。
DOI:
10.1249/mss.0000000000001489
发表时间:
2018
期刊:
Medicine and science in sports and exercise
影响因子:
4.1
作者:
[Coggan,AndrewR]
通讯作者:
Coggan,AndrewR
The Inorganic Nitrate and eXercise performance in Heart Failure (iNIX-HF): - a phase II clinical trial
-
批准号:10731565
-
项目类别:
-
资助金额:$73.72万
-
财政年份:2022
-
负责人:ANDREW R COGGAN
-
依托单位:
The Inorganic Nitrate and eXercise performance in Heart Failure (iNIX-HF): - a phase II clinical trial
-
批准号:10449833
-
项目类别:
-
资助金额:$80.38万
-
财政年份:2022
-
负责人:ANDREW R COGGAN
-
依托单位:
THE INORGANIC NITRATE FOR EXERCISE IN HEART FAILURE (INIX-HF) TRIAL
-
批准号:9754867
-
项目类别:
-
资助金额:$22.93万
-
财政年份:2017
-
负责人:ANDREW R COGGAN
-
依托单位:
THE INORGANIC NITRATE FOR EXERCISE IN HEART FAILURE (INIX-HF) TRIAL
-
批准号:9374210
-
项目类别:
-
资助金额:$23.75万
-
财政年份:2017
-
负责人:ANDREW R COGGAN
-
依托单位:
EFFECT OF GENDER ON SUBSTRATE UTILIZATION DURING SUBMAXIMAL EXERCISE
-
批准号:6115180
-
项目类别:
-
资助金额:$3.42万
-
财政年份:1998
-
负责人:ANDREW R COGGAN
-
依托单位:
AGING AND SKELETAL MUSCLE FATTY ACID METABOLISM
-
批准号:2387920
-
项目类别:
-
资助金额:$14.26万
-
财政年份:1997
-
负责人:ANDREW R COGGAN
-
依托单位:
AGING AND SKELETAL MUSCLE FATTY ACID METABOLISM
-
批准号:2769437
-
项目类别:
-
资助金额:$12.25万
-
财政年份:1997
-
负责人:ANDREW R COGGAN
-
依托单位:
AGING AND SKELETAL MUSCLE FATTY ACID METABOLISM
-
批准号:2832413
-
项目类别:
-
资助金额:$12.7万
-
财政年份:1997
-
负责人:ANDREW R COGGAN
-
依托单位:
EFFECT OF GENDER ON SUBSTRATE UTILIZATION DURING SUBMAXIMAL EXERCISE
-
批准号:6276415
-
项目类别:
-
资助金额:$2.69万
-
财政年份:1997
-
负责人:ANDREW R COGGAN
-
依托单位:
FREE FATTY ACID AVAILABILITY ON PLASMA GLUCOSE KINETICS DURING EXERCISE
-
批准号:3882878
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:ANDREW R COGGAN
-
依托单位:
EFFECT OF GENDER ON SUBSTRATE UTILIZATION DURING SUBMAXIMAL EXERCISE
-
批准号:6305283
-
项目类别:
-
资助金额:$3.42万
-
财政年份:--
-
负责人:ANDREW R COGGAN
-
依托单位:
海外基金