PHARMACOKINETICS OF ANTITUBERCULOUS AGENTS IN HIV INFECTION

HIV 感染中抗结核药物的药代动力学

• 批准号: 6115213
• 负责人: JOHN E CONTE
• 金额: $ 5.16万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6115213
• 关键词: HIV infections; antitubercular agents; blood chemistry; bronchoscopy; clinical research; diagnostic respiratory lavage; ethambutol; human subject; isoniazid; oral administration; pharmacokinetics; pyrazinamide; respiratory pharmacology; rifamycins

Specific aims are to determine and compare: a) plasma pharmacokinetics of orally administered antituberculous agents, isoniazid, rifampin, pyrazinamide, ethambutol, + ethionamidein HIV+ & HIV- men & women, & b) intrapulmonary pharmacokinetics of these drugs by measuring drug concentrations in bronchoalveolar lavage fluid. This investigation consists of 5 studies (1 for each drug) involving 240 subjects. By performing bronchoscopy and bronchoalveolar lavage following last dose, intrapulmonary pharmacokinetics and serum concentrations will be compared.

具体目的是确定和比较：a)口服抗结核药物、异烟肼、利福平、吡嗪酰胺、乙胺丁醇、乙硫胺在HIV+和HIV-男性和女性中的血浆药代动力学；b)通过测量支气管肺泡灌洗液中药物浓度来测定这些药物的肺内药代动力学。本研究包括5项研究（每种药物1项），涉及240名受试者。末次给药后进行支气管镜检查和支气管肺泡灌洗，比较肺内药代动力学和血清浓度。