LOW SALT, HIGH SALT, & HIGH SALT W/ KHCO3 IN POSTMENOPAUSAL WOMEN

低盐、高盐、

• 批准号: 6264377
• 负责人: ANTHONY SEBASTIAN
• 金额: $ 5.16万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6264377
• 关键词: 1,25 dihydroxycholecalciferol; bicarbonates; blood chemistry; bone metabolism; calcium; creatinine; cyclic AMP; dietary sodium; female; human subject; nutrition related tag; osteocalcin; parathyroid hormones; phosphates; postmenopause; potassium; salt intake; sodium; urinalysis

In this study postmenopausal women will have baseline markers of bone metabolism including serum calcium, phosphate, alk phos, sodium, potassium, creatinine, chloride, osteocalcin, PTH, and calcitriol, and 24-hour urine sodium, calcium, deoxypyridinoline, creatinine, potassium, and cyclic AMP. The women will then be adapted to a low salt diet for four weeks and these outcomes repeated. Then they will be randomized to a high salt diet with placebo or a high salt diet with potassium bicarbonate for four weeks and the outcomes repeated.

在这项研究中，绝经后女性将有骨代谢的基线标志物，包括血清钙、磷酸盐、烷磷酸、钠、钾、肌酐、氯、骨钙素、PTH和骨化三醇，以及24小时尿钠、钙、脱氧吡啶啉、肌酐、钾和环磷酸腺苷。然后，这些女性将适应低盐饮食四个星期，并且这些结果会重复。 然后，他们将被随机分配到高盐饮食加安慰剂或高盐饮食加碳酸氢钾，为期四个星期，并重复结果。