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EFFECT OF KHCO3 ON RATE OF BONE MASS DECLINE IN PRE AND POSTMENOPAUSAL WOMEN

EFFECT OF KHCO3 ON RATE OF BONE MASS DECLINE IN PRE AND POSTMENOPAUSAL WOMEN
KHCO3 对绝经前和绝经后妇女骨量下降率的影响
批准号：
6276454
负责人：
ANTHONY SEBASTIAN
金额：
$6.43万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6276454
关键词：
bicarbonates biopsy bone density chemoprevention clinical research drug screening /evaluation female human subject longitudinal human study menstrual cycle osteoporosis postmenopause potassium

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中文摘要
翻译
本研究旨在比较KHCO_3和安慰剂在减轻或预防 绝经后妇女与年龄相关的骨量下降。 经皮髂动脉 将在服用KHCO3或 安慰剂2年。这是为了确定新骨是否正在形成 在KHCO3给药期间，组织学正常。 这是一 我们的GCRC和加州大学洛杉矶分校的GCRC之间的合作研究。 骨活检 样本将由CORE实验室处理，并送至UCLA CORE实验室， 分析.
英文摘要
This study is to compare KHCO3 & placebo in attenuating or preventing age-related bone mass decline in postmenopausal women. Percutaneous iliac crest bone biopsies will be done in women who have been taking KHCO3 or placebo for 2 yrs. This is to determine if the new bone being formed duriing KHCO3 administration is histologically normal. This is a cooperative study between our GCRC and the GCRC at UCLA. Bone biopsy specimens will be processed by the CORE lab and sent to UCLA CORE Lab for analysis.
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LOW SALT, HIGH SALT, & HIGH SALT W/ KHCO3 IN POSTMENOPAUSAL WOMEN
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