EFFECT OF KHCO3 ON RATE OF BONE MASS DECLINE IN PRE AND POSTMENOPAUSAL WOMEN

KHCO3 对绝经前和绝经后妇女骨量下降率的影响

• 批准号: 6246386
• 负责人: ANTHONY SEBASTIAN
• 金额: $ 4.89万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-02-04 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6246386
• 关键词: bicarbonates; biopsy; bone density; chemoprevention; clinical research; drug screening /evaluation; female; human subject; longitudinal human study; menstrual cycle; osteoporosis; postmenopause; potassium

This study is to compare KHCO3 and placebo in attenuating or preventing age-related bone mass decline in postmenopausal women. Percutaneous iliac crest bone biopsies will be done in women who have been taking KHCO3 or placebo for 2 yrs. This is to determine if the new bone being formed duriing KHCO3 administration is histologically normal. This is a cooperative study between our GCRC and the GCRC at UCLA. Bone biopsy specimens will be processed by the CORE lab and sent to UCLA CORE Lab for analysis.

本研究旨在比较KHCO3和安慰剂在减轻或预防 绝经后妇女与年龄相关的骨量下降。 经皮 髂嵴骨活检将在服用 KHCO3或安慰剂2年。这是为了确定新骨是否 KHCO3给药期间形成的组织学正常。 这是一 我们的GCRC和加州大学洛杉矶分校的GCRC之间的合作研究。 骨活检 样本将由CORE实验室处理，并送至UCLA CORE实验室， 分析.