KINETIC MASS BALANCE MODEL FOR 1,5 ANHYDROGLUCITOL TO MONITOR GLYCEMIA CONTROL.

人血浆中存在的多元醇1，5-脱水葡萄糖醇(AG)是 主要来源于摄取，未经代谢排泄出来。一个 各种多元醇也会在糖尿病的组织中积聚，它们的 浓度可以用同位素稀释质谱仪来测量。 糖尿病患者血浆(AG)的降低已被注意到，这是由于 高血糖时AG排泄加速。血浆[AG]具有 因此，有人建议将其作为血糖控制的指标。一个精准的 对其效用的理解依赖于对 AG的质量平衡。在这项研究中，非稳态数据被 分析建立了AG的动态质量平衡模型，该模型基于 在两间房的模型上。该数据与模型中的 组织和血浆池之间的交换是快速的，其中 组织间隔室的质量是 血浆舱。根据模型估计，加速 高血糖引起的AG排泄可导致明显的净排空 在天数的时间范围内占总AG的比例。从耗尽的状态中恢复 是慢的，因为总的身体容量相当于正常的5周 入口处。因此，AG监测应该能够指示 在一段时期内出现既往的高血糖发作 几天到几周，以及提供信息，说明 与平均血糖浓度的高偏差是 行动中。

The polyol 1,5-anhydroglucitol (AG) present in human plasma is derived largely from ingestion and is excreted un-metabolized. A variety of polyols also accumulate in tissues of diabetes, and their concentrations can be measured by isotope dilution mass spectrometry. Reduction of plasma (AG) has been noted in diabetics and is due to accelerated excretion of AG during hyperglycemia. Plasma [AG] has therefore been proposed as a marker for glycemic control. A precise understanding of its utility relies on a quantitative understanding of the mass balance for AG. In this study, non-steady-state data were analyzed to develop a dynamic mass balance model for AG that is based on a two-compartment model. The data was consistent with a model in which exchange between tissue and plasma pools is rapid and in which the tissue compartment mass is two to three times the mass of the plasma compartment. According to model estimates, accelerated excretion of AG due to hyperglycemia can c ause marked net depletion of total AG over a time scale of days. Recovery from a depleted state is slow because the total body capacity represents >5 wk of normal intake. Accordingly, AG monitoring should be able to indicate the presence of past glucosuric hyperglycemic episodes during a period of days to weeks, as well as provide information on the extent to which high deviations from the average plasma glucose concentration are operative.