Development of novel methods for non-invasive measurement of cardiac output and lung volume during anaesthesia

开发麻醉期间无创测量心输出量和肺容量的新方法

• 批准号: nhmrc : 211001
• 负责人: A. Baker
• 金额: $ 17.2万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Development Grants
• 财政年份: 2002
• 资助国家: 澳大利亚
• 起止时间: 2002-01-01 至 2004-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/development-novel-methods-volume-anaesthesia/76212
• 关键词: Development; novel; methods; non; invasive

In Australia approximately 2 million anaesthetic procedures are performed annually. Approximately one patient in 20,000 dies during or shortly after an anaesthetic from complications related to the anaesthetic itself, and as many as one in 170 suffers severe complications. Mortality and severe morbidity are often ultimately associated with lack of oxygen in the tissues. Oxygen is transported from the lungs to the tissues by the blood. The oxygen content of arterial blood is monitored by pulse oximetry during every anaesthetic, but blood flow is not. Cardiac output is measured in only a very small proportion of anaesthetised patients using intravenous catheters that pass through the heart to the lungs. This procedure is invasive and is associated with significant morbidity and mortality. At present there is no easy way to monitor cardiac output non-invasively during anaesthesia. Our proposed research project, currently underway in conjunction with an industrial partner, is aimed at the development of a reliable, rapidly repeating, non-invasive method for monitoring total cardiac output and lung volume in every patient who has an anaesthetic. The purpose of the new monitor is to ensure that potential problems with oxygen supply to the tissues are detected and corrected promptly. Our new monitoring technique is computer-controlled, can function without intervention by the anaesthetist and has very few side-effects. It can be added to any anaesthetic machine. Such a measurement technique is likely to have an impact on anaesthesia similar to that of pulse oximetry in the 1980's, and, if suitably adapted, is likely to find applications in other fields, such as intensive care, sports medicine, the respiratory function laboratory and in veterinary medicine.

在澳大利亚，每年大约进行 200 万例麻醉手术。大约 20,000 名患者中就有 1 名患者在麻醉期间或麻醉后不久死于与麻醉本身相关的并发症，多达 170 名患者中就有 1 名患有严重并发症。死亡和严重发病通常最终与组织缺氧有关。氧气通过血液从肺部输送到组织。每次麻醉期间都会通过脉搏血氧仪监测动脉血的氧含量，但血流量则不然。只有极少数麻醉患者使用穿过心脏到达肺部的静脉导管来测量心输出量。该手术是侵入性的，并且与显着的发病率和死亡率相关。目前还没有一种简单的方法可以在麻醉期间无创地监测心输出量。我们提议的研究项目目前正在与工业合作伙伴合作进行，旨在开发一种可靠、快速重复、非侵入性的方法，用于监测每位麻醉患者的总心输出量和肺容量。新监测仪的目的是确保及时发现并纠正组织供氧的潜在问题。我们的新监测技术是计算机控制的，无需麻醉师干预即可发挥作用，并且副作用很少。它可以添加到任何麻醉机中。这种测量技术可能会对麻醉产生类似于 20 世纪 80 年代脉搏血氧测定法的影响，并且如果适当调整，可能会在其他领域找到应用，例如重症监护、运动医学、呼吸功能实验室和兽医学。