EFFECT OF CLARITHROMYCIN ON CYTOCHROME P450 ENZYMES

克拉霉素对细胞色素 P450 酶的影响

• 批准号: 6117853
• 负责人: BARBARA HAEHNER
• 金额: $ 1.7万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6117853
• 关键词: biomarker; blood chemistry; caffeine; clarithromycin; clinical research; clinical trials; cytochrome P450; dextromethorphan; enzyme activity; high performance liquid chromatography; human subject; tolbutamide; urinalysis

The primary objective of this study is to determine the effects of clarithromycin on the cytochrome P450 enzymes 1A1/2, 2D6, 3A4 and 2C8/9 using caffeine, dextromethorphan, tolbutamide and their metabolic products as markers. In the first phase, patients will first have their metabolic markers and their metabolic products measured. The patients will then take a course of at least seven days of clarithromycin to initiation of the second phase. The metabolic markers will be readministered and they and their metabolic products measured. The serum and rine samples collected from volunteers will be analyzed by high pressure liquid chromatography.

这项研究的主要目的是确定 细胞色素P450酶1A1/2、2d6、3A4和2C8/9上的Clarithromycin 使用咖啡因，右美甲苯甲酸盐，Tolbutamide及其代谢产物 作为标记。 在第一阶段，患者将首先具有代谢 标记及其代谢产物测量了。 然后患者将 服用至少七天的克拉霉素的过程 第二阶段。 代谢标记将被重新掌握，它们 及其代谢产物测量了。 血清和rine样品 从志愿者那里收集的将通过高压液体分析 色谱法。