MATERNAL CAFFEINE USE IN PREGNANCY OUTCOME

母亲摄入咖啡因在不良妊娠反应发病机制中的作用 妊娠结局有争议。 多项研究发现， 摄入咖啡因的妇女自然流产的风险增加 和胎儿发育迟缓的风险。 然而，其他的， 同样出色的研究也发现咖啡因没有有害作用 消费 此外，一些研究报告说，咖啡因是 只对吸烟的女性有害。 以前所有关于这个问题的研究都依赖于母亲报告的 咖啡因使用;没有研究使用咖啡因的生物标志物。 这 该项目将首先验证血清咖啡因及其代谢物的使用 作为咖啡因摄入量的标志，然后将研究这些血清标志物， 作为不良妊娠结局的风险因素。 在验证研究中， 血清副黄嘌呤被确定为咖啡因的可接受标记物 摄入 该项目的主要部分于1997财政年度开始。 在这一部分中， 副黄嘌呤，咖啡因的主要代谢产物， 比较700名经历自然流产的妇女和 2800名活产妇女，在分娩的同时抽取血清， 妊娠为自发性流产。此外该 胎儿生长迟缓与妊娠晚期副黄嘌呤的关系 将在这2800名妇女中评价血清浓度。

The role of maternal caffeine consumption in the pathogenesis of adverse pregnancy outcomes in controversial. Several studies have found that women who consume caffeine are at increased risk of spontaneous abortion and fetal growth retardation compared to non-users. However, other, equally well-done studies have found no harmful effects of caffeine consumption. In addition, several studies have reported that caffeine is harmful only among women who smoke. All previous studies of this question have relied on maternally-reported caffeine use; no studies have employed a biomarker for caffeine. This project will first validate the use of serum caffeine and its metabolites as a marker for caffeine intake, and will then study these serum markers as a risk factor for adverse pregnancy outcome. In the validation study, serum paraxanthine was determined to be an acceptable marker for caffeine intake. The main part of this project commenced in FY 97. In this portion, the serum concentration of paraxanthine, caffeine's primary metabolite, will be compared between 700 women experiencing a spontaneous abortion and 2800 women with live births who had serum drawn at the same time of pregnancy as the women with sponatneous loss. In addition, the association between reduced fetal growth and third-trimester paraxanthine serum concentrations will be evaluated among these 2800 women.