课题基金 / 基金详情

GANCICLOVIR/CIDOFOVIR CMV RETINITIS TRIAL

GANCICLOVIR/CIDOFOVIR CMV RETINITIS TRIAL
更昔洛韦/西多福韦 CMV 视网膜炎试验
批准号：
6291129
负责人：
JOSEPH WHEAT
金额：
$0.04万
依托单位：
INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6291129
关键词：
AIDS antiviral agents clinical research clinical trials cytomegalovirus retinitis eye disorder chemotherapy ganciclovir human subject human therapy evaluation

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中文摘要
翻译
更昔洛韦和西多福韦CMV视网膜炎试验（GCCRT）是一项研究两种治疗方案，不使用中心静脉导管管理新诊断和复发的艾滋病相关的CMV视网膜炎。 两种方案是：1）更昔洛韦眼内装置+口服更昔洛韦和2）静脉注射西多福韦。 该试验的主要目的是比较最新的CMV视网膜炎药物西多福韦（cidofovir）与常用的治疗方案更昔洛韦眼内装置加口服更昔洛韦（ganciclovir）在预防视力丧失方面的疗效。 第二个目的是比较一个治疗方案，包括高活性的局部治疗（更昔洛韦装置）与治疗方案，不。
英文摘要
The Ganciclovir and Cidofovir CMV Retinitis Trial (GCCRT) is a study of two treatment regimens that are administered without the use of a central venous catheter for both newly diagnosed and relapsed AIDS-related CMV retinitis. The two regimens are: 1) ganciclovir intraocular device plus oral ganciclovir and 2) intravenous cidofovir. The primary objective of the trial is to compare the newest CMV retinitis drug, cidofovir, to a commonly used treatment regimen, the ganciclovir intraocular device plus oral ganciclovir, with respect to efficacy in preventing vision loss. A secondary objective is to compare a treatment regimen that incorporates highly active local therapy (the ganciclovir device) with a treatment regimen that does not.
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