METHODS FOR ASSESSING MEDICATIONS TO LOWER ETOH: INTAKE FIELD STUDY

该研究的主要目的是开发评估药物引起的人类酒精摄入量减少的行为机制的方法。虽然新的药物被用来控制酗酒者的酒精摄入量，但人们对这些药物如何改变酒精对人的影响知之甚少。本研究的目的是开发一种行为评估电池，以测量在现场酒精自我管理协议中社交饮酒者的冲动和刺激。这些刺激和冲动的行为测量的效用将在社交饮酒者中进行评估，预先使用三剂纳曲酮中的一剂。纳曲酮是FDA批准的用于降低酒精摄入量的药物疗法。

The primary aim of the research proposed to develop methods for assessing the behavioral mechanisms underlying medication-induced decreases in alcohol intake in humans. Although new medications are being introduced to control alcohol intake in alcoholics, little is known about how these medications actually change the effects of alcohol in people. The purpose of this study is to develop a behavioral assessment battery to measure urge and stimulation in social drinkers during a field alcohol self-administration protocol. The utility of these behavioral measures of stimulation and urge will be assessed in social drinkers, pretreated with one of three doses of naltrexone. Naltrexone is an FDA approved pharmacotherapy for lowering alcohol consumption.