METHODS FOR ASSESSING MEDICATIONS TO LOWER ETOH INTAKE

这个重新提交的申请是一个指导研究的请求 科学家发展奖（KO 1）由NIAAA。 我对一个 研究生涯，加上我的兴趣，在接收专业 培训进行高质量的酒精治疗研究 滥用和依赖使KO 1奖成为最佳资金来源， 我职业生涯的阶段。 在KO 1的资助下，我学会了如何 独立设计、实施和分析行为药理学 人类受试者的研究。 我将与我的导师，博士密切合作。 罗伯特·斯威夫特和布朗大学的其他核心教员一起， 酒精和成瘾研究中心（CAAS） 我的教育的一部分 培训将包括参加所有CAAS学术课程 活动 我还将定期出席国际会议 在我的领域 本申请中提出的研究的主要目的是 开发评估行为机制的方法， 药物诱导的人类酒精摄入量减少。 虽然新 正在引入药物来控制酒精摄入量， 对于酗酒者，人们对这些药物的实际变化知之甚少。 酒精对人体的影响建议进行两项研究， 酒精的影响，通常被认为是重要的，以维持 问题饮酒和诱发复发饮酒。 第一项研究 将开发刺激社交饮酒者的行为措施， 一个受控的实验室酒精给药方案 第二 研究将应用这些行为刺激措施，并进一步 在社交饮酒者中开发我们的冲动行为测量方法， 酒精自我给药方案这些行为的效用 刺激和冲动的措施将通过预处理进行评估 受试者接受三种剂量的纳洛酮（NTX）之一。 NTX是一个 减少酒精引起的主观刺激的药物治疗， 酒精渴望和酒精摄入。 总的来说，这一时期的资金 将用于：1）为我提供必要的培训，以开始 酒精滥用和依赖的独立研究生涯; 2）发展 测量酒精对刺激和渴望的影响的新方法; （3）评估不同剂量NTX对这些行为的影响。

This resubmitted application is a request for a Mentored Research Scientist Development Award (KO1) from NIAAA. My commitment to a research career, together with my interest in receiving specialized training to conduct high quality research in the treatment of alcohol abuse and dependence make a KO1 award the optimum funding source at this stage of my career. With funding from a KO1, I learn how to independently design, implement and analyze behavioral pharmacology studies with human subjects. I will work closely with my mentor, Dr. Robert Swift, and with other core faculty members at Brown University's Center for Alcohol and Addiction Studies (CAAS). Part of my didactic training will include participating in all CAAS academic program activities. I will also regularly present at international conferences in my field. The primary aim of the research proposed in this application is to develop methods for assessing the behavioral mechanisms underlying medication-induced decreases in alcohol intake in humans. Although new medications are being introduced to control alcohol intake in alcoholics, little is known about how these medications actually change the effects of alcohol in people. Two studies are proposed to assess alcohol effects that are often considered to be important to maintaining problem drinking and precipitating relapse drinking. The first study will develop behavioral measures of stimulation in social drinkers using a controlled, laboratory alcohol administration protocol. The second study will apply these behavioral measures of stimulation and further develop our behavioral measures of urge in social drinkers using a field a alcohol self-administration protocol. The utility of these behavioral measures of stimulation and urge will be assessed by pre-treating subjects with one of three doses of naltrexone (NTX). NTX is a pharmacotherapy that decreases alcohol-induced subjective stimulation, alcohol craving and alcohol intake. In summary, this period of funding will be used to: 1) provide me with the necessary training to begin an independent research career in alcohol abuse and dependence; 2) develop new methods for measuring alcohol's effects on stimulation and craving; and 3) assess the effects of different doses of NTX on these behaviors.