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PHASE II STUDY OF INTERMITTENT RECOMBINANT HUMAN INTERLEUKIN-2 BY INTRAVENOUSLY

PHASE II STUDY OF INTERMITTENT RECOMBINANT HUMAN INTERLEUKIN-2 BY INTRAVENOUSLY
间歇性静脉注射重组人白介素-2 的 II 期研究
批准号：
6118449
负责人：
RONALD T. MITSUYASU
金额：
$0.19万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6118449
关键词：
AIDS therapy CD4 molecule antiAIDS agent antiviral agents clinical research clinical trial phase I drug administration rate /duration drug administration routes drug screening /evaluation drug tolerance human subject human therapy evaluation interleukin 2 intravenous administration leukocyte count microorganism disease chemotherapy quality of life recombinant proteins

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中文摘要
翻译
比较两种不同的间歇给予重组人白细胞介素2和高效抗逆转录病毒疗法和单独进行高效抗逆转录病毒治疗的受试者在接受重组人白细胞介素2治疗一年后，CD4细胞计数比随机前基线增加50%以上的受试者的比例和CD4细胞计数的变化率。这项研究将比较这些方案的安全性、耐受性和对生活质量的影响。
英文摘要
To compare two different routes of intermittently administered rhIL-2 with a highly active antiretroviral regimen to highly active antiretroviral therapy alone with respect to the proportion of subjects achieving greater than or equal to 50% increase in CD4 counts above prerandomization baseline values after one year of rhIL-2 and the rate of change in CD4 counts. This study will compare the safety, tolerance, and effect on quality of life of these regimens.
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