EFFECTS OF ESTRADIOL ON ANTERIOR CRUCIATE LIGAMENT

女性运动员前交叉韧带损伤的风险更高。雌激素受体已被确定在人类前交叉韧带。 暴露于雌二醇的前交叉韧带在体内显示胶原蛋白形成减少。 内源性雌二醇的浓度可能对前交叉韧带松弛和僵硬有影响。 我们在本研究中招募了10名受试者。 2例受试者因不明原因退出研究，2例受试者的血样在处理过程中丢失。 对其余6名受试者的分析显示，其余6名受试者的关节疼痛显著减少，这与峰值周期中期雌二醇水平相关（p=0.03）。 这项研究已经结束，但已导致提交AivCast基金会赠款，以进一步探索这种关系。

Female athletes have a higher risk of anterior cruciate ligament injury. Estrogen receptors have been identified in the human anterior cruciate ligament. Anterior cruciate ligaments exposed to estradiol in vivo have shown decreased collagen formation. The concentration of endogenous estradiol may have an effect on anterior cruciate ligament laxity and stiffness. We enrolled 10 subjects in this study. Two subjects dropped out of the study for undetermined reasons and two subjects blood samples were lost in processing. Analysis of the remaining six subjects showed a remaining six subjects had a significant decrease in joint soreness associated with peak mid-cycle estrodiol levels (p=0.03). This study has been closed but has led to the submission of an AivCast Foundation grant to further explore this relationship.