POSTPARTUM INSULIN SENSITIVITY IN WOMEN WITH TYPE I DIABETES MELLITUS

患有 I 型糖尿病的女性产后胰岛素敏感性

• 批准号: 6279413
• 负责人: SUSAN E KIRK
• 金额: $ 3.19万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6279413
• 关键词: clinical research; female; human subject; hypoglycemia; insulin dependent diabetes mellitus; insulin sensitivity /resistance; medical complication; postpartum; pregnancy disorder

Postpartum hypoglycemia is a frequent complication in pregnancy complicated by Type I diabetes. Although the antepartum increase in insulin resistance is well-documented, little is known about insulin sensitivity in the postpartum period. Placental GH shares many of the biologic properties of pituitary GH, and is secreted in increasing amounts during pregnancy. Its disappearance from the circulation coincides with the time period of frequent hypoglycemia. We plan to measure insulin sensitivity in women with and without Type I diabetes mellitus.

产后低血糖是妊娠期常见的并发症 并发I型糖尿病 虽然产前增加， 胰岛素抵抗是有据可查的，但对胰岛素的了解很少 产后敏感性。 胎盘GH分享了许多 垂体生长激素的生物学特性，并分泌增加 量在怀孕期间。 从流通中消失 与频繁低血糖的时间段一致。 我们计划 测量患有和不患有I型糖尿病的女性的胰岛素敏感性 糖尿病。