The use of Advanced MRI techniques to evaluate antenatal lung development.

使用先进的 MRI 技术来评估产前肺部发育。

基本信息

批准号：
MR/W019469/1
负责人：
Mary Ann Rutherford
金额：
$ 130.95万
依托单位：
King's College London
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2022
资助国家：
英国
起止时间：
2022 至无数据
项目状态：
未结题

来源：
https://gtr.ukri.org/projects?ref=MR%2FW019469%2F1
关键词：
use Advanced MRI techniques evaluate

项目摘要

Inadequate development of the lungs (known as pulmonary hypoplasia) is a relatively common event, occurring in 1 in 1000 pregnancies. In 50% of these babies the lungs are too small for long term survival after birth. Risk factors include rupture of the membranes before twenty-four weeks with loss of the amniotic fluid surrounding the baby or the presence of a congenital abnormality of the baby's heart or chest At present, in clinical practice, the size of the baby's lungs can be evaluated during the pregnancy using either ultrasound or basic magnetic resonance imaging (MRI). The latter are safe scans which use magnets to create images of the baby. Estimated size gives some information about whether a baby will survive after birth but neither of these assessments provide detailed information about alterations in lung development such as how the air spaces are forming or indicate how the lungs might function after birth. Advanced MRI techniques could provide more in depth information about both normal and abnormal lung development. This study will use these advanced MRI techniques to see how babies' lungs develop in the womb during normal pregnancies (100 pregnancies). We will then assess 70 pregnancies at high risk of pulmonary hypoplasia to assess the specific alterations in lung development that occur in this condition. All women will undergo an MRI scan during their pregnancy. In women with uncomplicated pregnancies this will be once during the pregnancy between 16 and 42 weeks. In women with pregnancies at risk of pulmonary hypoplasia we will perform two MRI scans, one when we identify them as high risk and another later in the pregnancy. We will collect information on the babies after birth such as if they survive, need oxygen or other treatments to help them breathe. After birth we will also assess how the lungs are functioning using a technique called helium dilution. During this safe test the baby breathes in helium (a non-harmful gas) which allows us to calculate the actual size of the babies' lungs. In the future this new knowledge may help individualize counselling as to how a baby's lungs are likely to function after birth. Currently women who lose the waters around the baby early in the pregnancy or have other abnormalities with the chest or heart are given the option of termination of pregnancy due to the high risk of pulmonary hypoplasia however some children do survive although with varying qualities of life. These new MRI scans may also help to monitor potential treatments aimed at improving lung growth and development such as surgery or medications administered in the womb.

肺部发育不足（称为肺部发育不全）是一个相对常见的事件，发生在1000名妊娠中的1个。在这些婴儿中，有50％的肺太小，无法长期生存。危险因素包括在二十四个星期之前破裂，围绕婴儿的羊水损失或目前婴儿心脏或胸部的先天性异常，在临床实践中，可以使用超声或基本的磁共振成像（MRI）评估婴儿肺的大小。后者是安全的扫描，它使用磁铁来创建婴儿的图像。估计的大小提供了一些有关婴儿是否在出生后生存的信息，但这些评估都没有提供有关肺部发育变化的详细信息，例如空间如何形成或指示肺在出生后如何起作用。先进的MRI技术可以提供有关正常和异常肺发育的深入信息。这项研究将使用这些先进的MRI技术，以查看正常怀孕期间婴儿肺如何在子宫中发育（100例怀孕）。然后，我们将评估70种肺部发育不全风险高的妊娠，以评估这种情况下发生的肺发育的特定变化。所有妇女在怀孕期间将接受MRI扫描。在单纯怀孕的妇女中，这将是在16至42周之间的怀孕期间。在患有肺部发育不全风险的怀孕妇女中，我们将进行两次MRI扫描，其中一项将其识别为高风险，而在怀孕后期。我们将在出生后收集有关婴儿的信息，例如生存，需要氧气或其他疗法来帮助他们呼吸。出生后，我们还将使用称为氦稀释的技术评估肺部如何发挥作用。在这项安全测试中，婴儿呼吸氦气（一种无害的气体），这使我们能够计算婴儿的肺部实际尺寸。将来，这种新知识可能会帮助对婴儿的肺在出生后可能运作的方式来个性化咨询。目前，由于肺部发育不全的高风险，尽管怀孕期早期就失去了婴儿周围的水域，或者胸部或心脏有其他异常。这些新的MRI扫描也可能有助于监测旨在改善肺部生长和发育的潜在治疗方法，例如在子宫内服用的手术或药物。