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The use of Advanced MRI techniques to evaluate antenatal lung development.

使用先进的 MRI 技术来评估产前肺部发育。

基本信息

批准号：
MR/W019469/1
负责人：
Mary Ann Rutherford
金额：
$ 130.95万
依托单位：
King's College London
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2022
资助国家：
英国
起止时间：
2022 至无数据
项目状态：
未结题

来源：
https://gtr.ukri.org/projects?ref=MR%2FW019469%2F1
关键词：
use Advanced MRI techniques evaluate

项目摘要

Inadequate development of the lungs (known as pulmonary hypoplasia) is a relatively common event, occurring in 1 in 1000 pregnancies. In 50% of these babies the lungs are too small for long term survival after birth. Risk factors include rupture of the membranes before twenty-four weeks with loss of the amniotic fluid surrounding the baby or the presence of a congenital abnormality of the baby's heart or chest At present, in clinical practice, the size of the baby's lungs can be evaluated during the pregnancy using either ultrasound or basic magnetic resonance imaging (MRI). The latter are safe scans which use magnets to create images of the baby. Estimated size gives some information about whether a baby will survive after birth but neither of these assessments provide detailed information about alterations in lung development such as how the air spaces are forming or indicate how the lungs might function after birth. Advanced MRI techniques could provide more in depth information about both normal and abnormal lung development. This study will use these advanced MRI techniques to see how babies' lungs develop in the womb during normal pregnancies (100 pregnancies). We will then assess 70 pregnancies at high risk of pulmonary hypoplasia to assess the specific alterations in lung development that occur in this condition. All women will undergo an MRI scan during their pregnancy. In women with uncomplicated pregnancies this will be once during the pregnancy between 16 and 42 weeks. In women with pregnancies at risk of pulmonary hypoplasia we will perform two MRI scans, one when we identify them as high risk and another later in the pregnancy. We will collect information on the babies after birth such as if they survive, need oxygen or other treatments to help them breathe. After birth we will also assess how the lungs are functioning using a technique called helium dilution. During this safe test the baby breathes in helium (a non-harmful gas) which allows us to calculate the actual size of the babies' lungs. In the future this new knowledge may help individualize counselling as to how a baby's lungs are likely to function after birth. Currently women who lose the waters around the baby early in the pregnancy or have other abnormalities with the chest or heart are given the option of termination of pregnancy due to the high risk of pulmonary hypoplasia however some children do survive although with varying qualities of life. These new MRI scans may also help to monitor potential treatments aimed at improving lung growth and development such as surgery or medications administered in the womb.

肺发育不全（称为肺发育不全）是一种相对常见的事件，发生在1/1000怀孕。这些婴儿中有50%的肺部太小，无法在出生后长期存活。风险因素包括24周前胎膜破裂，婴儿周围羊水丢失或婴儿心脏或胸部先天性异常。目前，在临床实践中，婴儿肺部的大小可以在怀孕期间使用超声或基本磁共振成像（MRI）进行评估。后者是安全的扫描，使用磁铁来创建婴儿的图像。估计的大小提供了一些关于婴儿出生后是否能存活的信息，但这些评估都没有提供有关肺部发育变化的详细信息，例如空气空间如何形成或表明出生后肺部如何发挥功能。先进的MRI技术可以提供有关正常和异常肺发育的更深入的信息。这项研究将使用这些先进的MRI技术来观察婴儿的肺部在正常怀孕期间（100次怀孕）在子宫内的发育情况。然后，我们将评估70例肺发育不良高危妊娠，以评估这种情况下发生的肺发育的特定变化。所有女性在怀孕期间都将接受MRI扫描。对于无并发症妊娠的妇女，这将在妊娠16至42周期间进行一次。在有肺发育不良风险的孕妇中，我们将进行两次MRI扫描，一次是在我们确定为高风险时，另一次是在怀孕后期。我们将收集婴儿出生后的信息，例如他们是否存活，是否需要氧气或其他治疗来帮助他们呼吸。出生后，我们还将使用一种称为氦稀释的技术来评估肺部的功能。在这个安全的测试中，婴儿吸入氦气（一种无害的气体），这使我们能够计算出婴儿肺部的实际大小。在未来，这些新知识可能有助于个性化咨询，以了解婴儿出生后肺部可能如何发挥功能。目前，由于肺发育不良的高风险，在怀孕早期失去婴儿周围的沃茨或胸部或心脏有其他异常的妇女可以选择终止妊娠，但有些儿童确实存活下来，尽管生活质量不同。这些新的MRI扫描也可能有助于监测旨在改善肺部生长和发育的潜在治疗，如手术或子宫内给药。

项目成果

期刊论文数量（4）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Assessment of the fetal lungs in utero.

DOI：
10.1016/j.ajogmf.2022.100693
发表时间：
2022-09
期刊：
American journal of obstetrics & gynecology MFM
影响因子：
6.3
作者：
通讯作者：

Reliability and Feasibility of Low-Field-Strength Fetal MRI at 0.55 T during Pregnancy

怀孕期间 0.55 T 低场强胎儿 MRI 的可靠性和可行性

DOI：
10.1148/radiol.223050
发表时间：
2023
期刊：
Radiology
影响因子：
19.7
作者：
Aviles Verdera J
通讯作者：
Aviles Verdera J

An automated pipeline for quantitative T2* fetal body MRI and segmentation at low field

用于定量 T2* 胎儿体 MRI 和低场分割的自动化流程

DOI：
10.1007/978-3-031-43990-2_34
发表时间：
2023
期刊：
ArXiv
影响因子：
0
作者：
K. Payette;Alena Uus;Jordina Aviles Verdera;C. Zampieri;M. Hall;L. Story;Maria Deprez;M. Rutherford;J. Hajnal;S. Ourselin;Raphaël Tomi;J. Hutter
通讯作者：
J. Hutter