CHIMERA SOFTWARE DEVELOPMENT

奇美拉软件开发

• 批准号: 6119132
• 负责人: CONRAD C HUANG
• 金额: $ 0.54万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 2000-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6119132
• 关键词: biomedical resource; computers; informatics; model design /development; technology /technique

Chimera is our next generation molecular graphics application whose main design goals are extensibility and ease of use. Chimera is being written in Python with C++ extensions and uses commonly accepted application programmer interface (API) specifications such as the ``Tk'' (TCL toolkit) for it's graphical user interface and OpenGL for three- dimensional graphics primitives. In addition, Chimera also uses the locally developed Object Technology Framework object class library for manipulating molecular data. Because program extensibility is a major design goal for this project, we chose to use a complete programming language (Python) as the Chimera command language. This will allow users to create complex Chimera command ``scripts'' (e.g. iterative loops and conditional execution), which in turn will allow sophisticaed operations to be perfromed on multiple molecular models. Python is an interpreted language with an extensive library that includes interfaces to Tk, which means users will be able to easily create their own custom graphical user interface (GUI) elements (such as menus and dialog boxes) as part of their extensions. Chimera itself is implemented with a small set of core functionality, including graphical display, Protein Data Bank (PDB) input, and basic user interface elements (menu bars, tool bar, command line, reply window and status line). More advanced features are constructed on top of the core using Python extension modules. This results in a program architecture in which new functionality is easily added when needed. In fact, we have used this basic extension mechanism to much of the standard functionality present in Chimera, since it is both fast and easy to program this way, and it insures that the small set of core functions we do provide are adequate to build whatever extensions a user may desire. Recent Chimera development has been focused on removing its previous dependence on Motif and OpenInventor. (Motif is a GUI window manager that is popular on UNIX-based workstations but is not commonly used on other platforms such as Microsoft Windows or Apple Macintosh. OpenInventor is an object-oriented interface to the popular OpenGL graphics package, but only Silicon Graphics currently has OpenInventor available for their workstations.) Removing Chimera's dependence on Motif and OpenInventor increases the portability of Chimera significantly, particularly with respect to Windows NT. A number of user interface elements have also recently been added (e.g., mouse panel, lenses, and selection panel). Two new extensions to Chimera (a Multiple Sequence Format (MSF) file viewer and a stru cture alignment viewer) are also under development and were demonstrated at our Advisory Committee meeting on March 16, 1998; they were well received.

Chimera是我们的下一代分子图形应用程序 其主要设计目标是可扩展性和易用性。 嵌合体是 用Python编写，带有C++扩展，并使用普遍接受的 应用程序编程接口（API）规范，例如 “Tk”（TCL工具包）用于其图形用户界面，而OpenGL用于 三维图形基元。 此外，Chimera还 使用本地开发的对象技术框架对象类 用于操作分子数据的库。 因为程序 可扩展性是这个项目的主要设计目标，我们选择使用 完整的编程语言（Python）作为Chimera命令 语言 这将允许用户创建复杂的Chimera命令 “脚本”（例如迭代循环和条件执行），在 turn将允许在多个 分子模型 Python是一种解释性语言，具有广泛的 一个包含Tk接口的库，这意味着用户将能够 轻松创建自己的自定义图形用户界面（GUI） 元素（如菜单和对话框）作为其扩展的一部分。 Chimera本身是用一小部分核心功能实现的， 包括图形显示，蛋白质数据库（PDB）输入，和基本的 用户界面元素（菜单栏、工具栏、命令行、回复 窗口和状态行）。 更高级的功能构建在 使用Python扩展模块的核心顶部。 这导致 一种程序体系结构，当 needed. 事实上，我们已经使用了这个基本的扩展机制， Chimera中存在的标准功能，因为它既是 快速和容易编程这种方式，它确保了小集 我们提供的核心功能足以构建 用户可能需要的扩展。 最近的嵌合体发展一直是 专注于消除以前对Motif和OpenInventor的依赖。 （Motif是一个GUI窗口管理器，在基于UNIX的 工作站，但不常用于其他平台， Microsoft Windows或Apple Macintosh。 OpenInventor是一个 面向对象的接口，以流行的OpenGL图形包，但 目前只有Silicon Graphics提供OpenInventor， 工作站）。消除Chimera对Motif和OpenInventor的依赖 显著增加了Chimera的便携性，特别是 关于Windows NT 许多用户界面元素也 最近被添加的（例如，鼠标面板、镜头和选择面板）。 Chimera的两个新扩展（多序列格式（MSF）文件 查看器和结构对齐查看器）也正在开发中 并在3月16日的咨询委员会会议上展示， 1998年，受到好评。