MACROMOLECULAR MODELS FOR CELL BIOLOGY CD ROM TEACHING TOOL

我正在制作一张CD-ROM，它利用了 酵母菌和科学史为细胞学科提供了背景 生物学包括生物化学、遗传学和分子生物学。这个 该计划是为初中及以上的学生准备的。 困难的生物学概念通过繁重的 使用图形、动画，尤其是令人兴奋的视觉数据 由世界各地的研究实验室产生。MidasPlus软件和 加州大学旧金山分校计算机图形实验室的设施使我能够 实验并创造出许多吸引人的多肽和核 具有一致图形处理和空间处理的ACID图像 方向。我还制作了一个3-D代谢物模型库 以相同的方式呈现。我最近专注于一项 将作为主菜单的酵母生命周期动画 获取科学数据和随附的动画。我也是 制作生物过程的卡通模型，将其与 大分子结构数据。我刚刚完成了一个序列， 展示了受体如何介导G蛋白信号转导，第二信使 系统和激活级联起作用。GTP、GDP、 ATP、ADP等被用来代替字母，许多动画片 可以点击链接到PDB结构数据的图形输出。 除了图形，还有关于蛋白质数据和 提供了酵母菌基因座的定位。这种类型的视觉 信息管理不仅使学生的学习变得更容易 也解决了蛋白质的一些交叉引用超载问题 基因组数据库也在苦苦挣扎。

I am producing a CD-ROM that utilizes both the model system of yeast and the history of science to contextualize the subject of cell biology including biochemistry, genetics and molecular biology. The program is geared for students from junior high school and up. Difficult biological concepts are made accessible through the heavy use of graphics, animation and especially exciting visual data generated by research labs around the world. MidasPlus software and the facilities of the UCSF Computer Graphics Lab have allowed me to experiment with, and create many appealing polypeptide and nucleic acid images with consistent graphic treatment and spatial orientations. I also have made a library of 3-D metabolite models rendered in the same manner. I have recently concentrated on an animation of the yeast life cycle that will serve as the main menu for access to scientific data and accompanying animations. I am also making cartoon models of biological processes that link to the macromolecular structural data. I have just finished a sequence that shows how receptor mediated G-protein signaling, second messenger systems and kinase cascades work. Color coded 3-D models of GTP, GDP, ATP, ADP etc. are used instead of letters, and many of the cartoons can be clicked to link to graphic output of PDB structural data. Along with the graphics, information about the protein data and the location of yeast gene loci are provided. This type of visual information management not only makes learning for students easier it also solves some of the cross-reference overload problems that protein and genome databases are struggling with.