MACROMOLECULAR & METABOLITE MODELS FOR CELL BIOLOGY: CD ROM TEACHING TOOL

高分子

• 批准号: 6280162
• 负责人: TOM DALLMAN
• 金额: $ 0.02万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-01 至 1999-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6280162
• 关键词: biological products; biomedical resource; computers; education; plants

I am creating a CD-ROM using yeast as a model system to contextualize the subject of cell biology (including biochemistry, genetics and molecular biology). A historical time-line illustrating important biological and chemical discoveries and a section tracing the yeast industry (from farms to sugar refineries to bakeries, breweries, wineries and distilleries) are included. I used MidasPlus Software to render an cohesive graphics library of polypeptide and nucleic acid images from the PDB database. I also generated a large library of metabolic intermediates in PDB format using LEAP (part of the AMBER molecular dynamics simulation software) and rendered the output in the same manner as the PDB database files. These components provide a visual key to biochemistry and regulation that will serve as a teaching aid, especially for those not predisposed to biology. All the graphics are keyed into information from the Brookhaven Data Bank and the Saccharomyces genome database which makes these and other resources more available to the average student . Over the past year, I have concentrated on the historical aspect by making and rendering molecular models that illustrate how our modern concepts of chemistry and crystallography arose. Experiments performed by the pneumatic chemists of the 1700's, ie. Black, Cavendish, Priestley, Lavoissier illustrated with today's MidasPlus graphic output not only place important concepts relating photosynthesis, respiration, combustion and fermentation in a tangible and intriguing setting they relate simple molecular models with the complicated models found in the PDB database. Demystification of the eye catching images produced by today's science is necessary to help students think critically. I also made an animation of the yeast life cycle that will serve as a background for the MidasPlus graphic output I generated along with detailed animation's of DNA replication, signal transduction, and oxidative phosphorylation.

我正在创建一张使用酵母作为模型系统的CD-ROM 将细胞生物学(包括生物化学， 遗传学和分子生物学)。一条历史时间线说明 重要的生物和化学发现和一段追踪 酵母业(从农场到糖厂再到面包店， 包括酿酒厂、葡萄酒厂和酿酒厂)。我用的是MidasPlus 用于绘制多肽和多肽的内聚图形库的软件 来自PDB数据库的核酸图像。我还产生了一个巨大的 使用LEAP的PDB格式的代谢中间体库(部分 琥珀分子动力学模拟软件)，并渲染 以与PDB数据库文件相同的方式输出。这些组件 提供生物化学和监管的可视化钥匙，将作为 生物教具一种教具，尤指为那些对生物不感兴趣的人而用全 这些图形被输入到布鲁克海文数据库的信息中 以及酵母基因组数据库，它使这些和其他 更多的资源可供普通学生使用。在过去一年里， 我已经通过制作和渲染集中在历史方面 分子模型说明了我们的现代化学概念 结晶学应运而生。由气动执行的实验 1700年的化学家S，即。布莱克、卡文迪什、普里斯特利、拉沃西耶 用今天的MidasPlus图形输出说明的不仅仅是地方 与光合作用、呼吸作用、燃烧有关的重要概念 以及在有形和耐人寻味的环境中的发酵 简单分子模型与PDB中的复杂模型 数据库。揭开由中国制造的醒目图像的神秘面纱 今天的科学是必要的，以帮助学生进行批判性思考。我 还制作了酵母生命周期的动画，将作为 我生成的MidasPlus图形输出的背景 详细的DNA复制、信号转导和 氧化磷酸化。