MACROMOLECULAR & METABOLITE MODELS FOR CELL BIOLOGY: CD ROM TEACHING TOOL

高分子

• 批准号: 6280162
• 负责人: TOM DALLMAN
• 金额: $ 0.02万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-01 至 1999-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6280162
• 关键词: biological products; biomedical resource; computers; education; plants

I am creating a CD-ROM using yeast as a model system to contextualize the subject of cell biology (including biochemistry, genetics and molecular biology). A historical time-line illustrating important biological and chemical discoveries and a section tracing the yeast industry (from farms to sugar refineries to bakeries, breweries, wineries and distilleries) are included. I used MidasPlus Software to render an cohesive graphics library of polypeptide and nucleic acid images from the PDB database. I also generated a large library of metabolic intermediates in PDB format using LEAP (part of the AMBER molecular dynamics simulation software) and rendered the output in the same manner as the PDB database files. These components provide a visual key to biochemistry and regulation that will serve as a teaching aid, especially for those not predisposed to biology. All the graphics are keyed into information from the Brookhaven Data Bank and the Saccharomyces genome database which makes these and other resources more available to the average student . Over the past year, I have concentrated on the historical aspect by making and rendering molecular models that illustrate how our modern concepts of chemistry and crystallography arose. Experiments performed by the pneumatic chemists of the 1700's, ie. Black, Cavendish, Priestley, Lavoissier illustrated with today's MidasPlus graphic output not only place important concepts relating photosynthesis, respiration, combustion and fermentation in a tangible and intriguing setting they relate simple molecular models with the complicated models found in the PDB database. Demystification of the eye catching images produced by today's science is necessary to help students think critically. I also made an animation of the yeast life cycle that will serve as a background for the MidasPlus graphic output I generated along with detailed animation's of DNA replication, signal transduction, and oxidative phosphorylation.

我正在创建一个CD-ROM，使用酵母作为模型系统， 将细胞生物学（包括生物化学， 遗传学和分子生物学）。 一条历史时间线， 重要的生物和化学发现和一段追踪 酵母工业（从农场到糖厂到面包店， 酿酒厂、葡萄酒厂和酿酒厂）。 我用的是MidasPlus 用于绘制多肽的内聚图形库的软件， PDB数据库中的核酸图像。 我还生成了一个大的 使用LEAP的PDB格式的代谢中间体库（ AMBER分子动力学模拟软件）， 以与PDB数据库文件相同的方式输出。 这些组件 为生物化学和调节提供了一个视觉上的关键， 一种教学辅助工具，尤指对那些没有生物学倾向的人。 所有 这些图形被输入到布鲁克海文数据库的信息中 和酵母基因组数据库，使这些和其他 资源更多地提供给普通学生。 在过去的一年里， 我把注意力集中在历史方面， 这些分子模型说明了我们现代的化学概念 晶体学出现了。 实验由气动 1700年的化学家，即。 布莱克，卡文迪什，普里斯特利，拉瓦锡 说明与今天的MidasPlus图形输出不仅地方 有关光合作用、呼吸作用、燃烧的重要概念 和发酵在一个有形的和有趣的设置， 简单的分子模型与PDB中的复杂模型 数据库 揭开神秘的眼睛捕捉图像产生的 今天的科学必须帮助学生进行批判性思考。 我 我还制作了一个酵母生命周期的动画， 我沿着生成的MidasPlus图形输出的背景 详细的动画的DNA复制，信号转导， 氧化磷酸化