MACROMOLECULAR MODELS FOR CELL BIOLOGY CD ROM TEACHING TOOL

细胞生物学大分子模型光盘教学工具

• 批准号: 6456694
• 负责人: TOM DALLMAN
• 金额: $ 27.32万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6456694
• 关键词: AIDS; biological products; biomaterials; biomedical resource; biotechnology; immunology; infection; inflammation; lymphatic system; technology /technique; virus

I am producing a CD-ROM that utilizes both the model system of yeast and the history of science to contextualize the subject of cell biology including biochemistry, genetics and molecular biology. The program is geared for students from junior high school and up. Difficult biological concepts are made accessible through the heavy use of graphics, animation and especially exciting visual data generated by research labs around the world. MidasPlus software and the facilities of the UCSF Computer Graphics Lab have allowed me to experiment with, and create many appealing polypeptide and nucleic acid images with consistent graphic treatment and spatial orientations. I also have made a library of 3-D metabolite models rendered in the same manner. I have recently concentrated on an animation of the yeast life cycle that will serve as the main menu for access to scientific data and accompanying animations. I am also making cartoon models of biological processes that link to the macromolecular structural data. I have just finished a sequence that shows how receptor mediated G-protein signaling, second messenger systems and kinase cascades work. Color coded 3-D models of GTP, GDP, ATP, ADP etc. are used instead of letters, and many of the cartoons can be clicked to link to graphic output of PDB structural data. Along with the graphics, information about the protein data and the location of yeast gene loci are provided. This type of visual information management not only makes learning for students easier it also solves some of the cross-reference overload problems that protein and genome databases are struggling with.

我正在制作一张 CD-ROM，它同时使用了以下模型系统： 酵母和科学史来背景化细胞主题 生物学包括生物化学、遗传学和分子生物学。 这 该计划适合初中及以上的学生。 困难的生物学概念可以通过沉重的负担变得容易理解 使用图形、动画和特别令人兴奋的视觉数据 由世界各地的研究实验室生成。 MidasPlus 软件和 加州大学旧金山分校计算机图形实验室的设施使我能够 实验并创造出许多有吸引力的多肽和核酸 具有一致图形处理和空间的酸性图像 方向。 我还制作了一个 3D 代谢物模型库 以同样的方式渲染。 我最近专注于一个 酵母生命周期的动画，将作为主菜单 访问科学数据和随附的动画。 我也是 制作与生物过程相关的卡通模型 大分子结构数据。 我刚刚完成了一个序列 显示受体如何介导 G 蛋白信号传导（第二信使） 系统和激酶级联起作用。 GTP、GDP 的颜色编码 3D 模型 用ATP、ADP等代替字母，很多漫画 可以单击链接到 PDB 结构数据的图形输出。 除了图形之外，还有有关蛋白质数据和 提供了酵母基因座的位置。 这种类型的视觉 信息管理不仅让学生的学习变得更加轻松 还解决了蛋白质的一些交叉引用过载问题 和基因组数据库正在苦苦挣扎。