ANALYSIS OF HORMONE BINDING DOMAIN (HBD) OF THYROID HORMONE RECEPTOR (TR)

甲状腺激素参与了对两者的调节。 发育和新陈代谢。主要激素-三碘甲腺原氨酸(T3)， 结合核受体(Tr)，调节转录。 调节荷尔蒙反应的基因产物。树对T3的结合 诱导构象变化，从而改变调节性质 感受器的。我们对荷尔蒙作用机制的理解 结合调节受体活性将通过一种结构来推进 在2.0E分辨率下，结合了T3的TR配体结合域。 该结构域主要由阿尔法螺旋组成，并揭示了 荷尔蒙的意外结合模式，荷尔蒙埋藏在其中 在受体内作为疏水核心的一部分。

Thyroid hormones are involved in the regulation of both development and metabolism. The major hormone-triiodothyronine (T3), binds a nuclear receptor (TR) which regulates the transcription of the gene products that mediate hormone response. Binding of T3 by TR induces a conformational change that alters the regulatory properties of the receptor. Our understanding of the mechanism by which hormone binding regulates receptor activity would be advanced by a structure of the TR ligand binding domain with T3 bound, at 2.0 E resolution. The domain consists largely of alpha helices, and reveals an unexpected binding mode for hormone, in which the hormone buried within the receptor as part of the hydrophobic core.