甲状腺激素 RECP 配体结合域 (LBD) 的衍生数据-猫眼课题宝

甲状腺激素 RECP 配体结合域 (LBD) 的衍生数据

批准号：

6586568

负责人：

RICHARD L WAGNER

金额：

$14.32万

依托单位：

STANFORD UNIVERSITY

依托单位国家：

美国

项目类别：

财政年份：

2002

资助国家：

美国

项目状态：

已结题

起止时间：

2002-03-01 至 2003-02-28

来源：

https://reporter.nih.gov/project-details/6586568

关键词：

bioimaging /biomedical imaging biomaterials biomedical resource endocrine gland /system growth /development radiography structural biology

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中文摘要

翻译

甲状腺激素参与两者的调节

英文摘要

Thyroid hormones are involved in the regulation of both development and metabolism. The major hormone -triiodothyronine (T3), binds a nuclear receptor (TR) which regulates the transcription of the gene products that mediate hormone response. Binding of T3 by TR induces a conformational change that alters the regulatory properties of the receptor. Our understanding of the mechanism by which hormone binding regulates receptor activity would be advanced by a structure of the TR ligand binding domain with T3 bound, at 2.0E resolution. The domain consists largely of alpha helices, and reveals an unexpected binding mode for hormone, in which the hormone buried within the receptor as part of the hydrophobic core.

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