DERIVATIVE DATA FOR LIGAND BINDING DOMAIN (LBD) OF THYROID HORMONE RECP

甲状腺激素参与了这两种调节 发育和新陈代谢。 主要激素-三碘甲状腺原氨酸（T3）， 结合核受体（TR），其调节核受体的转录。 调节激素反应的基因产物。 TR与T3的结合 诱导构象变化，从而改变调节特性 的受体。 我们对激素作用机制的理解 结合调节受体活性的结构 TR配体结合域与T3结合，2.0E分辨率。 该结构域主要由α螺旋组成，并揭示了 意想不到的结合模式的激素，其中激素埋 作为疏水核心的一部分。

Thyroid hormones are involved in the regulation of both development and metabolism. The major hormone -triiodothyronine (T3), binds a nuclear receptor (TR) which regulates the transcription of the gene products that mediate hormone response. Binding of T3 by TR induces a conformational change that alters the regulatory properties of the receptor. Our understanding of the mechanism by which hormone binding regulates receptor activity would be advanced by a structure of the TR ligand binding domain with T3 bound, at 2.0E resolution. The domain consists largely of alpha helices, and reveals an unexpected binding mode for hormone, in which the hormone buried within the receptor as part of the hydrophobic core.