COCRYSTAL STRUCTURE DATA OF HUMAN CYTOMEGALOVIRUS PROTEASE INHIBITOR COMPLEX

人巨细胞病毒蛋白酶抑制剂复合物的共晶结构数据

• 批准号: 6119436
• 负责人: Ping Chen
• 金额: --
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-03-01 至 2000-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6119436
• 关键词: biomaterials; proteins; virus

Human cytomegalovirus (HCMV) protease is a viral serine protease essential for proteolytic processing of the assembly of protein precursor during cytomegalovirus capsid maturation. Inhibitors to this protease may potentially be useful as antiviral agents for treating HCMV infection in transplant and immunocompromised patients. An X-ray structure of the HCMV protease catalytic domain apo enzyme was solved at Agouron and published in Cell, 86:835-843 (1996). We are taking the structure-based drug design approach to design inhibitors. Using the intense synchrotron X-ray beam we can obtain high resolution diffraction data of inhibitor complexes. The structure information will help to rationalize the structure-activity relationships of inhibitors and will aid the design and optimization of new inhibitors against herpesvirus proteases.

人巨细胞病毒（HCMV）蛋白酶是一种病毒丝氨酸蛋白酶