From proteins to virus particles: the structure and function of virions

从蛋白质到病毒颗粒：病毒粒子的结构和功能

• 批准号: MC_UU_00034/1
• 负责人: David Bhella
• 金额: $ 727.57万
• 依托单位: University of Glasgow
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MC_UU_00034%2F1
• 关键词: proteins; virus; particles; structure; function

Structural biology aims to understand how the shapes of the molecules of life, such as viral proteins, direct their functions. This is achieved by experimental determination of the 3D shape of biological molecules at the level of their individual atoms. Atomic structures can be combined with mathematical models of how molecules might move (molecular dynamics) and how they might evolve to evade host defences. Understanding the structure, dynamics and evolution of viral proteins can give researchers new ways to think about viral infections which can be tested in the laboratory. In this programme we will bring together expertise in structural biology (Bhella, Carter), molecular dynamics (Grove), mathematical modelling (Illingworth) and molecular and compositional biology (Hutchinson) to study the structure and function of virus particles (virions) of influenza viruses, coronaviruses and respiratory syncytial virus.

结构生物学旨在了解生命分子（如病毒蛋白质）的形状如何指导其功能。这是通过在其单个原子水平上实验确定生物分子的3D形状来实现的。原子结构可以与分子如何移动（分子动力学）以及它们如何进化以逃避宿主防御的数学模型相结合。了解病毒蛋白的结构、动力学和进化可以为研究人员提供新的方法来思考可以在实验室中测试的病毒感染。在这个计划中，我们将汇集结构生物学（Bhella，Carter），分子动力学（格罗夫），数学建模（伊林沃思）和分子和成分生物学（哈钦森）的专业知识，以研究流感病毒，冠状病毒和呼吸道合胞病毒的病毒颗粒（病毒粒子）的结构和功能。

项目成果

Low hanging fruit for combatting SARS-CoV-2?

对抗 SARS-CoV-2 的成果是否唾手可得？

• DOI: 10.15252/embr.202356979
• 发表时间: 2023
• 期刊: EMBO reports
• 影响因子: 7.7
• 作者: Cantoni D

GB Virus B and Hepatitis C Virus, Distantly Related Hepaciviruses, Share an Entry Factor, Claudin-1.

• DOI: 10.1128/jvi.00469-23
• 发表时间: 2023-07-27
• 期刊: JOURNAL OF VIROLOGY
• 影响因子: 5.4
• 作者: Toon, Kamilla;Kalemera, Mphatso D.;Palor, Machaela;Rose, Nicola J.;Takeuchi, Yasuhiro;Grove, Joe;Mattiuzzo, Giada
• 通讯作者: Mattiuzzo, Giada

The lipid linked oligosaccharide polymerase Wzy and its regulating co-polymerase, Wzz, from enterobacterial common antigen biosynthesis form a complex.

• DOI: 10.1098/rsob.220373
• 发表时间: 2023-03
• 期刊: Open biology
• 影响因子: 5.8

Multiplexed Biosensing of Proteins and Virions with Disposable Plasmonic Assays.

• DOI: 10.1021/acssensors.2c02238
• 发表时间: 2023-09-22
• 期刊: ACS SENSORS
• 影响因子: 8.9
• 作者: Wallace, Stephanie;Kartau, Martin;Kakkar, Tarun;Davis, Chris;Szemiel, Agnieszka;Samardzhieva, Iliyana;Vijayakrishnan, Swetha;Cole, Sarah;De Lorenzo, Giuditta;Maillart, Emmanuel;Gautier, Kevin;Lapthorn, Adrian J.;Patel, Arvind H.;Gadegaard, Nikolaj;Kadodwala, Malcolm;Hutchinson, Edward;Karimullah, Affar S.
• 通讯作者: Karimullah, Affar S.