From proteins to virus particles: the structure and function of virions

结构生物学的目标是了解生命分子的形状，如病毒蛋白，如何指导它们的功能。这是通过实验确定生物分子在其单个原子水平上的3D形状来实现的。原子结构可以与分子如何运动(分子动力学)以及它们可能如何进化以逃避宿主防御的数学模型结合起来。了解病毒蛋白的结构、动态和进化可以为研究人员提供新的方法来思考可以在实验室进行测试的病毒感染。在这个项目中，我们将汇集结构生物学(Bhella，Carter)、分子动力学(Grove)、数学建模(Illingworth)和分子和成分生物学(Hutchinson)的专业知识，研究流感病毒、冠状病毒和呼吸道合胞病毒的病毒粒子(病毒粒子)的结构和功能。

Structural biology aims to understand how the shapes of the molecules of life, such as viral proteins, direct their functions. This is achieved by experimental determination of the 3D shape of biological molecules at the level of their individual atoms. Atomic structures can be combined with mathematical models of how molecules might move (molecular dynamics) and how they might evolve to evade host defences. Understanding the structure, dynamics and evolution of viral proteins can give researchers new ways to think about viral infections which can be tested in the laboratory. In this programme we will bring together expertise in structural biology (Bhella, Carter), molecular dynamics (Grove), mathematical modelling (Illingworth) and molecular and compositional biology (Hutchinson) to study the structure and function of virus particles (virions) of influenza viruses, coronaviruses and respiratory syncytial virus.