BIOMIMETIC HEME CHEMISTRY

仿生血红素化学

• 批准号: 6120214
• 负责人: JAMES P COLLMAN
• 金额: $ 0.33万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-03-01 至 2000-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6120214
• 关键词: Mammalia; aging; animal tissue; biological products; biomedical resource; congenital disorders; infection; nervous system; proteins; spectrometry; structural biology

A series of novel, synthetic porphyrin complexes are being prepared and structurally characterized as functional models for several important heme systems: hemoglobin, myoglobin, cytochrome P-450, and cytochromec oxidase. This chemistry has led to a novel series of biomimetic oxygenation catalysts which exhibit shape-selectivity and chiral oxygenation. These are being examined for the preparation of chiral natural products, including terpenes and steroids. A series of myoglobin mimics are being prepared, structurally characterized and the thermodynamic/kinetic parameters for dioxygen binding are being measured. A new series of macrocycle/porphyrin sandwich compounds has been prepared and their iron derivatives have been analyzed in the context of their reversible binding of dioxygen and carbon monoxide. These substances show unprecedented low values of binding but normal values (myoglobin-like) for dioxygen binding. A synthetic analogue for the oxygen binding/activating site in cytochromec oxidase has been prepared. This consists of a macrocycle containing copper positioned over an iron porphyrin which has an axial imidazole bound on the opposite side. This complex binds dioxygen to form a peroxide.

一系列新颖的合成卟啉复合物正在 准备并在结构上表征为功能模型 几个重要的血红素系统：血红蛋白，肌红蛋白，细胞色素 P-450和细胞染料氧化酶。 这种化学导致了一本小说 表现出的一系列仿生氧合催化剂 形状选择性和手性氧合。 这些正在检查 用于制备手性天然产品，包括萜烯和 类固醇。 正在准备一系列肌红蛋白模仿， 结构表征和热力学/动力学参数 为了测量二氧化合物结合。 一个新系列 大环/卟啉三明治化合物已经制备，它们的 铁衍生物已在其可逆的背景下进行了分析 二氧化物和一氧化碳的结合。 这些物质显示 结合但正常值的前所未有的低值（类似肌红蛋白） 用于二氧化结合。 氧气的合成类似物 已经制备了细胞色素氧化酶中的结合/激活位点。 这是由一个含有铜的大环组成的 铁卟啉具有轴向咪唑在相对的轴向咪唑 边。 该复合物结合二氧化物形成过氧化物。