MODELS FOR CYTOCHROME P-450 HYDROXYLASES

一系列的合成铁卟啉正在制备的目的， 模拟氧结合血红素蛋白--血红蛋白、肌红蛋白和细胞色素 P-450 这些合成模型的结构正在通过X射线 衍射及其物理性质（穆斯堡尔，电子和MCD 光谱，磁矩和振动光谱）被确定为 与天然血红素蛋白相比。 特别强调的是 羟化酶细胞色素P-450模型的研究。 合成模型 P-450的低自旋和高自旋三价铁和羰基亚铁阶段具有 被定性。 合成的三聚氰胺的制备及结构表征 脱氧亚铁形式的类似物正在开发中。 钌类似物 正在制备这些铁卟啉，包括双氧络合物。 一个新 “帽状”卟啉和一系列广泛的二元“面对面”卟啉 已经准备好了。

A series of synthetic iron porphyrins are being prepared for the purpose of modelling the oxygen binding hemoproteins--hemoglobin, myoglobin, and cytochrome P-450. The structures of these synthetic models are being determined by X-ray diffraction and their physical properties (Mossbauer, electronic, and MCD spectra, magnetic moments, and vibrational spectra) are being determined for comparison with the natural hemoproteins. Special emphasis is being given to studies of models for the hydroxylase cytochrome P-450. Synthetic models for the low-spin and high-spin ferric and the ferrous carbonyl stages of P-450 have been characterized. Preparation and structural characterization of synthetic analogues of the deoxy ferrous form are progressing. Ruthenium analogues of these iron porphyrins are being prepared, including a dioxygen complex. A new "capped" porphyrin and an extensive series of binary "face-to-face" porphyrins have been prepared.