Development of potent and selective blockers of acid sensing ion channels for the treatment of pain

开发用于治疗疼痛的强效选择性酸敏感离子通道阻断剂

• 批准号: nhmrc : 1012338
• 负责人: Dr Lachlan Rash
• 金额: $ 38.59万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/development-potent-selective-treatment-pain/109650
• 关键词: Development; potent; selective; blockers; acid

More than three million Australians suffer from chronic pain, and there are few effective drugs available for treating this condition. A 2007 Access Economics Report estimated the economic burden of chronic pain in Australia at $34.3 billion. Acid-sensing ion channels (ASICs) are a recently discovered family of proteins that play a key role in sensing pain. The goal of this project is to develop potent blockers of these channels that can be used to treat patients suffering from persistent pain.

超过300万澳大利亚人患有慢性疼痛，并且几乎没有有效的药物可用于治疗这种疾病。2007年的一份《访问经济学报告》估计，澳大利亚慢性疼痛的经济负担为343亿美元。酸敏感离子通道（ASICs）是最近发现的一个蛋白质家族，在感知疼痛中发挥关键作用。该项目的目标是开发这些通道的有效阻断剂，可用于治疗持续性疼痛患者。