Examining the role of ASIC channels in pain through the development of subtype-specific ASIC channel modulators.

通过开发亚型特异性 ASIC 通道调制器来检查 ASIC 通道在疼痛中的作用。

• 批准号: nhmrc : 511067
• 负责人: Dr Lachlan Rash
• 金额: $ 41.16万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/examining-role-asic-channel-modulators/81382
• 关键词: Examining; role; ASIC; channels; pain

Acid sensing ion channels (ASICs) sense changes in acidity in the body. They are found throughout the body and may underlie nerve damage in stroke and some types of pain. ASICs also have many as yet unknown functions. A lack of selective tools to study ASICs is a major barrier to a complete understanding of what they do. This proposal aims to modify three animal toxins which block these receptors to make useful tools to study their function, in particular their role in sensing pain.

酸感应离子通道（ASIC）感应体内酸度的变化。它们遍布全身，可能是中风和某些类型疼痛的神经损伤的基础。ASIC还有许多未知的功能。缺乏研究ASIC的选择性工具是完全理解它们的主要障碍。该提案旨在修改三种阻断这些受体的动物毒素，使其成为研究其功能的有用工具，特别是它们在感知疼痛中的作用。