The regulation of inflammation in ventricular remodelling after myocardial infarction

炎症在心肌梗死后心室重构中的调控

• 批准号: MR/X001881/1
• 负责人: Daniel Bromage
• 金额: $ 186.57万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FX001881%2F1
• 关键词: regulation; inflammation; ventricular; remodelling; after

Heart failure (HF) is when the heart is unable to pump with enough force to meet the demands of the body. It frequently results from a heart attack (myocardial infarction or MI) causing impaired heart function. Despite current treatments, HF after MI causes significant morbidity and mortality. Inflammation, the body's response to harmful stimuli that is largely mediated by circulating white blood cells, is an important response to MI. However, there is compelling evidence implicating excessive inflammation in the development of post-MI HF. Certain types of inflammatory cells, called monocytes and macrophages, appear especially important. Blocking the influx of monocytes and macrophages after MI may prevent HF. This project aims to study the behaviour and molecular signalling of these cells after MI by manipulating a molecule called Nrf2, which is known to mitigate inflammation after a heart attack. It is hoped that these studies will identify new treatment targets with the ultimate aim of developing new ways of treating patients after MI to alleviate the development of HF.

心力衰竭（HF）是指心脏无法以足够的力量泵送以满足身体的需求。它通常由心脏病发作（心肌梗死或MI）引起，导致心脏功能受损。尽管目前的治疗方法，心肌梗死后的心力衰竭导致显著的发病率和死亡率。炎症是机体对有害刺激的反应，主要由循环白色血细胞介导，是对MI的重要反应。然而，有令人信服的证据表明过度炎症与MI后HF的发生有关。某些类型的炎症细胞，称为单核细胞和巨噬细胞，似乎特别重要。MI后阻断单核细胞和巨噬细胞的流入可预防HF。该项目旨在通过操纵一种名为Nrf2的分子来研究MI后这些细胞的行为和分子信号传导，Nrf2已知可以减轻心脏病发作后的炎症。希望这些研究将确定新的治疗靶点，最终目的是开发治疗MI后患者的新方法，以减轻HF的发展。

项目成果

Challenges in the Implementation of Medical Therapy in Heart Failure

心力衰竭药物治疗实施的挑战

• DOI: 10.1016/j.jchf.2023.04.001
• 发表时间: 2023
• 期刊: Heart Failure
• 作者: Jordan-Rios A

The prognostic impact of specialist cardiology input in patients admitted for heart failure and normal ejection fraction.

• DOI: 10.1002/ehf2.14440
• 发表时间: 2023-08
• 期刊: ESC heart failure
• 影响因子: 3.8

A changing heart in tako-tsubo syndrome.

tako-tsubo 综合征中心脏的变化。

• DOI: 10.1093/ehjci/jead112
• 发表时间: 2023
• 期刊: European heart journal. Cardiovascular Imaging
• 作者: Sen G

Prognostic Role of Contraindicated Drugs in Hospitalized Patients with Decompensated Heart Failure.

禁忌药物对失代偿性心力衰竭住院患者的预后作用。

• DOI: 10.1124/jpet.122.001413
• 发表时间: 2023
• 期刊: The Journal of pharmacology and experimental therapeutics
• 作者: Parish O

Treatment of Iron Deficiency in Heart Failure.

• DOI: 10.1007/s11886-023-01889-4
• 发表时间: 2023-07
• 期刊: CURRENT CARDIOLOGY REPORTS
• 影响因子: 3.7
• 作者: Shamsi, Aamir;Cannata, Antonio;Piper, Susan;Bromage, Daniel. I. I.;McDonagh, Theresa. A. A.
• 通讯作者: McDonagh, Theresa. A. A.