The potential importance of Stromal Derived Factor-1 in the protection and repair of myocardium following simulated ischaemia-reperfusion injury

基质衍生因子 1 在模拟缺血再灌注损伤后心肌保护和修复中的潜在重要性

• 批准号: MR/L002043/1
• 负责人: Daniel Bromage
• 金额: $ 31.06万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FL002043%2F1
• 关键词: potential; importance; Stromal; Derived; Factor

Following a heart attack, the restoration of blood flow to injured heart muscle can itself inflict injury, known as Ischaemia-Reperfusion Injury (IRI). Remote Ischaemic Conditioning (RIC) describes the phenomenon whereby the brief occlusion and restoration of blood flow to body tissues remote from the heart can protect heart muscle from IRI. However, despite promising results from experimental studies, the mechanism of action remains elusive. Recent attention has turned to a small protein called Stromal Cell-Derived Factor 1 (SDF-1), which is thought to have a dual function. Firstly, SDF-1 is thought to activate a protective mechanism that has previously been implicated in RIC, namely the Reperfusion Injury Salvage Kinase (RISK) pathway. Secondly, it is thought to play a role in attracting stem cells to the site of injury. It is therefore feasible that SDF-1 both protects heart muscle from IRI and helps repair it after injury, thus reducing heart failure. The key goals of my research are to demonstrate whether heart muscle can be protected from IRI in the presence of SDF-1 in animal models, and to ascertain the benefit of SDF-1 in preventing heart failure.

心脏病发作后，恢复血流到受伤的心肌本身可以造成伤害，称为缺血再灌注损伤（IRI）。远程缺血调节（RIC）描述了短暂阻断和恢复流向远离心脏的身体组织的血流可以保护心肌免受IRI的现象。然而，尽管实验研究的结果令人鼓舞，但作用机制仍然难以捉摸。最近的注意力转向了一种称为基质细胞衍生因子1（SDF-1）的小蛋白质，它被认为具有双重功能。首先，SDF-1被认为激活了先前与RIC有关的保护机制，即再灌注损伤补救激酶（RISK）途径。其次，它被认为在吸引干细胞到损伤部位方面发挥作用。因此，SDF-1既可以保护心肌免受IRI的影响，又可以在损伤后帮助修复，从而减少心力衰竭。本研究的主要目标是证明在动物模型中，SDF-1是否可以保护心肌免受IRI的影响，并确定SDF-1在预防心力衰竭方面的益处。

项目成果

The 10th Biennial Hatter Cardiovascular Institute workshop: cellular protection-evaluating new directions in the setting of myocardial infarction, ischaemic stroke, and cardio-oncology.

• DOI: 10.1007/s00395-018-0704-z
• 发表时间: 2018-10-11
• 期刊: Basic research in cardiology
• 影响因子: 9.5
• 作者: Davidson SM;Arjun S;Basalay MV;Bell RM;Bromage DI;Bøtker HE;Carr RD;Cunningham J;Ghosh AK;Heusch G;Ibanez B;Kleinbongard P;Lecour S;Maddock H;Ovize M;Walker M;Wiart M;Yellon DM
• 通讯作者: Yellon DM

Ventilation strategy has a major influence on remote ischaemic preconditioning in mice.

• DOI: 10.1111/jcmm.13164
• 发表时间: 2017-10
• 期刊: Journal of cellular and molecular medicine
• 影响因子: 5.3
• 作者: Davidson SM;He Z;Dyson A;Bromage DI;Yellon DM
• 通讯作者: Yellon DM

The pleiotropic effects of metformin: time for prospective studies.

• DOI: 10.1186/s12933-015-0273-5
• 发表时间: 2015-08-14
• 期刊: Cardiovascular diabetology
• 影响因子: 9.3
• 作者: Bromage DI;Yellon DM
• 通讯作者: Yellon DM

Outcome of 1051 Octogenarian Patients With ST-Segment Elevation Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention: Observational Cohort From the London Heart Attack Group.

• DOI: 10.1161/jaha.115.003027
• 发表时间: 2016-06-27
• 期刊: Journal of the American Heart Association
• 影响因子: 5.4
• 作者: Bromage DI;Jones DA;Rathod KS;Grout C;Iqbal MB;Lim P;Jain A;Kalra SS;Crake T;Astroulakis Z;Ozkor M;Rakhit RD;Knight CJ;Dalby MC;Malik IS;Mathur A;Redwood S;MacCarthy PA;Wragg A
• 通讯作者: Wragg A

MOESM1 of Metformin use and cardiovascular outcomes after acute myocardial infarction in patients with type 2 diabetes: a cohort study

2 型糖尿病患者急性心肌梗死后二甲双胍使用与心血管结局的 MOESM1：一项队列研究

• DOI: 10.6084/m9.figshare.11345585
• 发表时间: 2019
• 作者: Bromage D