MOLECULAR MECHANISM OF GENOMIC IMPRINTING: TUMOROGENIC PHENOTYPES

我感兴趣的是了解 一种非孟德尔式的遗传方式叫做基因组印记。 这是一个 哺乳动物中的一种基因调控类型，它区别于亲本 常染色体等位基因的起源 这样做的效果是沉默 亲本等位基因并激活印记基因座上的另一个等位基因。 这种类型的调节过程（染色体不平衡， 易位和其他突变）导致异常发育或 肿瘤发生表型 区分事件是在 发展或肿瘤发生表型。 区别事件 是在父母的生殖细胞系中开始的， 衍生的标记或印记，然后传输到 后代 本研究的目的是了解 印记的分子性质，印记如何稳定， 忠实地传递给胚胎，以及这些最终如何影响 跨膜活性 这些信息将改善我们的 对正常发展的理解，以及我们对 细胞转化中的分子事件。

I am interested in understanding the molecular basis of a non-Mendelian form of inheritance called genomic imprinting. It is a type of gene regulation in mammals that distinguishes the parental origin of autosomal alleles. The effect of this is to silence parental allele and activate the other allele at an imprinted locus. This type of regulatory process (chromosomal imbalances, translocation, and other mutations) result in abnormal development or tumorigenic phenotypes. The distinguishing events are initiated in the development or tumorigenic phenotypes. The distinguishing events are initiate in the parental germ lines, probably as epigentically derived markings or imprints, that are then transmitted to the offspring. The objectives of this research are to understand the molecular nature of the imprint, how the imprints are stably and faithfully transmitted to the embryo, and how these ultimately affect transriptional activity. This information will improve our understanding of normal development, as well as our understanding of molecular events in cellular transformation.