ROUTES TO CHIRAL CARBOCYCLIC AND HETEROCYCLIC COMPOUNDS

在过去的十几年里，通过探索手性非外消旋双环内酰胺的化学实现了非凡的成功，这要求我们继续研究一年。 我们已经发表了超过75篇论文和四篇关于这个显着的手性环系统的评论，随着我们继续逐步减少这种化学，出现了几个新的方向。 在这最后的延续请求中，我们将描述化学，它将访问一些重要类别的手性杂环（哌啶，吡咯烷，氮杂卓）以及多功能碳环，其结构迅速表明它们可以用于获得各种生物重要的化合物。

The extraordinary success realized by probing the chemistry of chiral, non-racemic bicyclic lactams over the past dozen years requires us to continue the investigation for one more year. We have published over 75 papers and four reviews on this remarkable chiral ring system and as we proceed to wind down this chemistry, several new directions appear. In this final continuation request we will describe chemistry which will access a number of important classes of chiral heterocycles (piperidines, pyrrolidines, azepines) as well as multifunctional carbocycles whose architecture quickly suggest they can be used to reach a variety of biologically important compounds.