COGNITIVE AND CEREBROVASCULAR SEQUELAE OF HYPERTENSION

高血压的认知和脑血管后遗症

• 批准号: 6183849
• 负责人: JOHN RICHARD JENNINGS
• 金额: $ 38.3万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 2001-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6183849
• 关键词: aging; atherosclerosis; brain circulation; cerebrovascular disorders; clinical research; cognition disorders; gender difference; human subject; hypertension; magnetic resonance imaging; neuropsychological tests; positron emission tomography

DESCRIPTION: Chronic diseases, which increase in prevalence with age, impair intellectual functioning. It has been shown that patients with essential hypertension have impaired performance on neuropsychological tests relative to age-matched controls. The mechanism by which hypertension impairs intellectual function is unknown. A likely possibility is that hypertension induces changes in the cerebral vasculature which are responsible for the neuropsychological impairments. Hypertension induces morphological changes (vascular remodeling) which may interfere with regional cerebral blood flow (rCBF) responses induced by information processing. Positron Emission Tomography (PET) functional brain imaging permits the investigators to test the hypothesis that hypertension impairs the rCBF response. With the advent of ultrasound measurements of the carotid arteries, the investigators can also test a second hypothesis that atherosclerosis influences intellectual function. This second hypothesis is considered because of the results available from the Kuopio Ischemic Heart Disease Study. Extent of carotid atherosclerosis was negatively related to intellectual functioning. Given that atherosclerosis could not be assessed in earlier studies of hypertension, it may be that only atherosclerosis is uniquely associated with intellectual impairments. Alternatively, heightened blood pressure and atherosclerosis may independently or interactively induce impairment. The investigators propose a project to test the hypothesis that hypertension alters neuropsychological function by damping the rCBF response to metabolic need created during information processing; and that carotid atherosclerosis adds to these impairments via the same mechanism. Measures of white matter lesions are also obtained to see if these may mediate the influences of hypertension and atherosclerosis. The hypothesis is tested by computing the contribution that hypertension and carotid atherosclerosis make directly and interactively to neuropsychological performance and rCBF in selected regions activated by performance tasks. The project attempts to identify mechanisms for how diseases of aging influence intellectual functioning. Successful completion will clarify a) how aging and the diseases of aging reduce intellectual functioning, and b) ultimately permit a rational choice of clinical regimen to treat the diseases of aging while minimizing neuropsychological side effects.

描述：慢性疾病，随着年龄的增长而增加患病率， 损害智力功能。 已经表明患者 基本高血压在神经心理学测试中的表现受损 相对于年龄匹配的控件。 高血压的机制 损害智力功能是未知的。 一个可能的可能性是 高血压引起大脑脉管系统的变化 负责神经心理学障碍。 高血压诱导 形态学变化（血管重塑）可能会干扰 信息引起的区域脑血流（RCBF）反应 加工。 正电子发射断层扫描（PET）功能性脑成像 允许研究人员检验高血压会损害的假设 RCBF响应。 随着超声测量的出现 颈动脉，研究人员还可以检验第二个假设 动脉粥样硬化影响智力功能。 第二个假设是 考虑到Kuopio缺血性心脏的结果 疾病研究。 颈动脉粥样硬化的程度与 智力功能。 鉴于无法评估动脉粥样硬化 在早期的高血压研究中，可能只有动脉粥样硬化是 与智力障碍的独特相关。 或者， 血压升高和动脉粥样硬化可能会独立或 互动诱导损害。 研究人员提出了一个测试高血压假设的项目 通过阻尼RCBF对代谢的反应来改变神经心理学功能 信息处理期间创建的需求；颈动脉粥样硬化 通过相同的机制增加了这些障碍。 白质的度量 还可以获得病变，以查看这些病变是否可以介导 高血压和动脉粥样硬化。 通过计算 高血压和颈动脉粥样硬化直接导致的贡献 在选定区域与神经心理学表现和RCBF交互式 通过性能任务激活。 该项目试图识别机制 衰老疾病如何影响智力功能。 成功的 完成将阐明a）衰老和衰老疾病如何减少 智力功能，b）最终允许合理选择 临床方案以治疗衰老的疾病，同时最大程度地减少 神经心理学副作用。