The Brain as a Target for Pre and Essential Hypertension

大脑作为高血压前期和原发性高血压的目标

基本信息

批准号：
8453400
负责人：
JOHN RICHARD JENNINGS
金额：
$ 40.23万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-04-02 至 2015-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8453400
关键词：
Affect Animals Appearance Area Atherosclerosis Attention Blood Pressure Blood Vessels Brain Brain Diseases Catecholamines Cerebrovascular Circulation Characteristics Clinical Cognitive Cognitive deficits Cross-Sectional Studies Development Diagnosis Diagnostic Diet Disease Essential Hypertension Family Human Hypertension Incidence Individual Intervention Light Lipids Longitudinal Studies Measures Medical Morphology Nervous System Physiology Parietal Participant Pathology Performance Persons Prefrontal Cortex Process Recording of previous events Relative (related person)Research Risk Factors Secondary to Short-Term Memory Sodium Chloride Stroke Structure Sympathetic Nervous System Testing Thalamic structure Variant Vascular Diseases aged aging brain design gray matter high risk indexing information processing neuropsychological normotensive pandemic disease peripheral blood pre-clinical premature public health relevance response success white matter

项目摘要

DESCRIPTION (provided by applicant): Essential hypertension is typically thought to attack the brain late in its course, primarily through stroke. Accumulating evidence from both human and animal studies, though, shows that essential hypertension is associated with mild cognitive deficits, altered cerebral blood flow, decreases in grey matter volume, altered sympathetic nervous system function, and signs of premature brain aging. This evidence suggests that the brain is an early target of the disease, and, perhaps, the initial target. We propose to establish this point by examining pre-hypertensive individuals to establish that the brain sequelae of the disease are present prior to diagnostic levels of high blood pressure. We propose a cross sectional study of 250 participants followed by a 2 year longitudinal study of 200 participants with initial blood pressures in the pre-hypertensive range. Presence of brain sequelae in pre-hypertensive individuals will suggest that the currently accepted view is no longer tenable, the view that the brain is only affected late in the disease. Longitudinal results should indicate whether brain alterations predict later blood pressure or both brain and vascular effects of the disease occur in parallel. Risk factors associated with hypertension will be closely examined to see if such factors may implicate co-occurring pathology rather than hypertension in the induction of brain alterations. Successful completion of the project should direct clinical attention toward early sequelae of essential hypertension in both the brain and vasculature.

描述（由申请人提供）：通常认为基本高血压在过程中主要是通过中风来攻击大脑。但是，来自人类和动物研究的证据积累的证据表明，基本高血压与轻度认知缺陷，大脑血流改变，灰质体积减少，交感神经系统功能的改变以及过早脑老化的迹象有关。该证据表明，大脑是该疾病的早期靶标，也许是最初的靶标。我们建议通过检查催眠前的个体来确定这一点，以确定该疾病的脑后遗症是在诊断出高血压水平之前存在的。我们建议对250名参与者进行横断面研究，然后对200名参与者进行了2年的纵向研究，并在高型前范围内具有初始血压。脑力学前的个体中的脑后遗症的存在会表明，当前接受的观点不再是可行的，这种观点认为大脑仅在疾病后期受到影响。纵向结果应表明大脑改变是否可以预测血压或脑的脑和血管作用并联。与高血压相关的危险因素将受到仔细检查，以查看此类因素是否可能暗示同时发生的病理学而不是高血压，而不是高血压。该项目的成功完成应将临床注意力转向大脑和脉管系统中必不可少的高血压的早期后遗症。