Development of selective melanocortin receptor agonists and antagonists

选择性黑皮质素受体激动剂和拮抗剂的开发

• 批准号: nhmrc : 1084604
• 负责人: Dr Christina Schroeder
• 金额: $ 45.65万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/development-selective-melanocortin-agonists-antagonists/519018
• 关键词: Development; selective; melanocortin; receptor; agonists

Human melanocortin receptors play a key role in a variety of physiological processes ranging from energy regulation, skin pigmentation and regulation of food intake. This project aims to generate novel peptide based molecules that will selectively interact with different melanocortin receptors to better understand their pharmacology thereby opening the potential for future drug development for obesity, stroke or inflammatory skin disorders.

人类黑素皮质素受体在能量调节、皮肤色素沉着和食物摄入调节等多种生理过程中发挥着关键作用。该项目旨在产生新的基于肽的分子，这些分子将选择性地与不同的黑素皮质素受体相互作用，以更好地了解它们的药理学，从而为肥胖、中风或炎症性皮肤疾病的未来药物开发开辟潜力。