Mechanism of interaction of VWC domains and consequence for protein function

VWC 结构域相互作用的机制及其对蛋白质功能的影响

• 批准号: nhmrc : 568804
• 负责人: Dr Christina Schroeder
• 金额: $ 34.46万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanism-interaction-vwc-protein-function/94474
• 关键词: Mechanism; interaction; VWC; domains; consequence

More than 1000 proteins contain a type of module known as the VWC domain. These domains are discreet sections of the protein that are very important for how the protein works. Proteins containing this domain are involved in normal functioning of the human body and in diseases of the nervous system and blood, among others. The main function of the VWC domain is to link proteins together in complexes. How this is achieved is not known and is what we aim to discover.

超过1000种蛋白质含有一种称为VWC结构域的模块。这些结构域是蛋白质的离散部分，对于蛋白质的工作方式非常重要。含有该结构域的蛋白质参与人体的正常功能以及神经系统和血液等疾病。VWC结构域的主要功能是将蛋白质连接在一起形成复合物。这是如何实现的尚不清楚，这是我们的目标是发现。