WEIGHT CONTROL IN PERI- AND EARLY POSTMENOPAUSAL WOMEN

围绝经期和绝经后早期女性的体重控制

• 批准号: 6348843
• 负责人: Susan Beth Racette
• 金额: $ 1.68万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6348843
• 关键词: adipose tissue; basal metabolism; behavior modification; behavioral /social science research tag; bioenergetics; body physical activity; body weight; calorimetry; clinical research; clinical trials; dietary lipid; dietary restriction; disease /disorder proneness /risk; female; human middle age (35-64); human subject; human therapy evaluation; lifestyle; menopause; nutrition education; nutrition related tag; postmenopause; social support network; weight control; women's health

Obesity is a preventable condition that contributes significantly to morbidity and mortality. A women's risk for obesity, as well as cardiovascular disease and osteoporosis, increases dramatically with menopause due to normal and lifestyle changes. Furthermore, many perimenopausal women are already at risk for obesity based upon current overweight or obesity, former obesity, or a family history of obesity. In light of much evidence that reversal of obesity generally is difficult and unsuccessful long-term, a preventive approach that emphasizes modest lifestyle modifications may be superior in promoting long-term behavioral changes and weight control with advancing age. Therefore, the primary aim of this study is to assess the effectiveness of a modest lifestyle intervention program or preventing gains in body weight, whole body bat mass, and abdominal adipose tissue during a 2-year period in perimenopausal and early postmenopausal women who are at risk for obesity. A second aim is to determine the effects of the intervention on daily physical activity, which will be calculated from total daily expenditure and resting metabolic rate, as determined by the doubly labeled water method and indirect calorimetry, respectively. A randomized, controlled trial will be used to evaluate the intervention in female employees of a large Midwestern medical center. The intervention is a modest lifestyle modification program that will focus on teaching participants ways to modify their dietary habits and incorporate additional physical activity, as a means of altering daily energy balance to prevent weight gain during the 2-year intervention period. The 4 components of the intervention include: 1) reducing dietary fat intake; 2) increasing daily physical activity; 3) two consecutive days per month of low-fat, low-calorie meals prepared either in the metabolic kitchen of the General Clinical Research Center or by the participant; and 4) a "study- buddy" system, in which each participant is paired with a buddy with whom she is to keep in the frequent contact, discuss goals and progress, and motive. The results of this project are intended to provide valuable information regarding lifestyle programs that may assist women in controlling body weight at a time when weight gain is common.

肥胖是一种可预防的疾病，它会显着增加发病率和死亡率。由于正常和生活方式的改变，随着更年期，女性患肥胖症、心血管疾病和骨质疏松症的风险急剧增加。此外，由于当前超重或肥胖、既往肥胖或肥胖家族史，许多围绝经期妇女已经面临肥胖风险。鉴于大量证据表明，从长远来看，逆转肥胖通常是困难且不成功的，强调适度改变生活方式的预防方法可能更能促进长期行为改变和随着年龄的增长而控制体重。因此，本研究的主要目的是评估适度的生活方式干预计划或预防有肥胖风险的围绝经期和绝经后早期女性在两年内体重、全身蝙蝠质量和腹部脂肪组织增加的有效性。第二个目标是确定干预措施对日常身体活动的影响，该影响将根据每日总支出和静息代谢率进行计算，分别通过双标记水法和间接热量测定法确定。一项随机对照试验将用于评估对中西部大型医疗中心女性员工的干预措施。该干预是一项适度的生活方式改变计划，重点是教导参与者如何改变饮食习惯并纳入额外的体育活动，作为改变日常能量平衡以防止两年干预期间体重增加的一种手段。干预措施的 4 个组成部分包括：1）减少膳食脂肪摄入量； 2）增加日常体力活动； 3) 每月连续两天在普通临床研究中心的代谢厨房或由参与者准备的低脂肪、低热量膳食； 4）“学习伙伴”系统，其中每个参与者都配有一个伙伴，她要与该伙伴保持经常联系，讨论目标和进展以及动机。该项目的结果旨在提供有关生活方式计划的有价值的信息，这些信息可以帮助女性在体重增加普遍的时期控制体重。