WEIGHT CONTROL IN PERI- AND EARLY POSTMENOPAUSAL WOMEN

围绝经期和绝经后早期女性的体重控制

• 批准号: 6381776
• 负责人: Susan Beth Racette
• 金额: $ 17.76万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至 2004-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6381776
• 关键词: adipose tissue; basal metabolism; behavior modification; behavioral /social science research tag; bioenergetics; body physical activity; body weight; calorimetry; clinical research; clinical trials; dietary lipid; dietary restriction; disease /disorder proneness /risk; female; human middle age (35-64); human subject; human therapy evaluation; lifestyle; menopause; nutrition education; nutrition related tag; postmenopause; social support network; weight control; women's health

Obesity is a preventable condition that contributes significantly to morbidity and mortality. A women's risk for obesity, as well as cardiovascular disease and osteoporosis, increases dramatically with menopause due to normal and lifestyle changes. Furthermore, many perimenopausal women are already at risk for obesity based upon current overweight or obesity, former obesity, or a family history of obesity. In light of much evidence that reversal of obesity generally is difficult and unsuccessful long-term, a preventive approach that emphasizes modest lifestyle modifications may be superior in promoting long-term behavioral changes and weight control with advancing age. Therefore, the primary aim of this study is to assess the effectiveness of a modest lifestyle intervention program or preventing gains in body weight, whole body bat mass, and abdominal adipose tissue during a 2-year period in perimenopausal and early postmenopausal women who are at risk for obesity. A second aim is to determine the effects of the intervention on daily physical activity, which will be calculated from total daily expenditure and resting metabolic rate, as determined by the doubly labeled water method and indirect calorimetry, respectively. A randomized, controlled trial will be used to evaluate the intervention in female employees of a large Midwestern medical center. The intervention is a modest lifestyle modification program that will focus on teaching participants ways to modify their dietary habits and incorporate additional physical activity, as a means of altering daily energy balance to prevent weight gain during the 2-year intervention period. The 4 components of the intervention include: 1) reducing dietary fat intake; 2) increasing daily physical activity; 3) two consecutive days per month of low-fat, low-calorie meals prepared either in the metabolic kitchen of the General Clinical Research Center or by the participant; and 4) a "study- buddy" system, in which each participant is paired with a buddy with whom she is to keep in the frequent contact, discuss goals and progress, and motive. The results of this project are intended to provide valuable information regarding lifestyle programs that may assist women in controlling body weight at a time when weight gain is common.

肥胖是一种可预防的疾病，极大地增加了发病率和死亡率。由于正常和生活方式的改变，随着更年期，女性患肥胖症、心血管疾病和骨质疏松症的风险急剧增加。此外，由于目前超重或肥胖、既往肥胖或家族肥胖史，许多围绝经期妇女已经面临肥胖的风险。鉴于许多证据表明，从长远来看，扭转肥胖通常是困难和不成功的，强调适度改变生活方式的预防性方法可能在促进长期行为变化和随着年龄增长控制体重方面更好。因此，这项研究的主要目的是评估适度的生活方式干预计划或预防有肥胖风险的围绝经期和早期绝经后妇女在两年期间体重、全身蝙蝠重量和腹部脂肪组织增加的有效性。第二个目标是确定干预对日常体力活动的影响，这将根据每日总支出和静息代谢率计算，分别通过双标记水法和间接量热法确定。一项随机对照试验将用于评估对中西部一家大型医疗中心女性员工的干预。这项干预是一项适度的生活方式调整计划，重点是教参与者如何改变饮食习惯，并进行额外的体力活动，作为一种改变日常能量平衡的手段，以防止在为期两年的干预期间体重增加。干预的4个组成部分包括：1)减少膳食脂肪摄入量；2)增加日常体力活动；3)每月连续两天在综合临床研究中心的代谢厨房或由参与者准备低脂肪、低卡路里的食物；4)“学习伙伴”系统，在该系统中，每个参与者都有一个与她保持频繁联系的伙伴，讨论目标和进展，以及动机。该项目的结果旨在提供有关生活方式计划的有价值的信息，这些计划可能有助于女性在体重增加普遍的情况下控制体重。