Prospective Investigation of Pulmonary Embolism Dx-II

肺栓塞 Dx-II 的前瞻性研究

• 批准号: 6334190
• 负责人: PAUL D STEIN
• 金额: $ 42.05万
• 依托单位: ST. JOSEPH MERCY OAKLAND
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-10 至 2004-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6334190
• 关键词: angiocardioultrasonography; angiography; bioimaging /biomedical imaging; clinical research; computed axial tomography; cooperative study; diagnosis design /evaluation; diagnosis quality /standard; human subject; lung imaging /visualization /scanning; noninvasive diagnosis; pulmonary circulation obstruction; respiratory disorder diagnosis; spirometry

This is a multicenter collaborative study to determine the sensitivity, specificity, positive and negative predictive value of contrast enhanced spiral computed tomography (spiral CT) for the diagnosis of acute pulmonary embolism (PE). Pulmonary embolism is common, yet frequently undiagnosed and fatal. Spiral CT is a nearly noninvasive test that offers the possibility of a definitive diagnosis of PE by showing the outline of the thrombus in a pulmonary artery. However, its utility in the diagnosis of PE is unknown. Even though spiral CT has not been adequately validated, physicians at many hospitals now use it as a definitive and only diagnostic test. This could lead to overtreatment or undertreatment, both of which have serious potential complications. The role of spiral CT in the diagnosis of PE requires an accurate evaluation which will be made in this investigation by a composite of diagnostic tests including pulmonary angiography, ventilation/perfusion lung scans, venous compression ultrasound and outcome analysis. The strengths of this proposal are: 1) the importance of the problem of PE in terms of lives lost from underdiagnosis, and major bleeding from overdiagnosis, and 2) the potential applicability of a new technology for the diagnosis of PE that will have widespread availability. 3) The protocol parallels standard diagnostic strategy, without subjecting the patients to risk entirely for the acquisition of data. 4) The team of investigators is strong, and has collaborated previously in successful research in PE.

这是一项多中心合作研究，旨在确定对比增强螺旋计算机断层扫描（螺旋 CT）诊断急性肺栓塞（PE）的敏感性、特异性、阳性和阴性预测值。 肺栓塞很常见，但常常未被诊断且致命。 螺旋 CT 是一种几乎无创的检查，通过显示肺动脉中血栓的轮廓，为 PE 的明确诊断提供了可能性。 然而，其在 PE 诊断中的效用尚不清楚。 尽管螺旋 CT 尚未得到充分验证，但许多医院的医生现在将其用作确定且唯一的诊断测试。 这可能导致过度治疗或治疗不足，这两种情况都有严重的潜在并发症。 螺旋CT在肺栓塞诊断中的作用需要进行准确的评估，在这项研究中，将通过包括肺血管造影、通气/灌注肺扫描、静脉加压超声和结果分析在内的综合诊断测试来进行评估。 该提案的优点是：1）PE 问题的重要性，因为诊断不足而导致生命损失，过度诊断导致大出血，2）广泛使用的诊断 PE 的新技术的潜在适用性。 3) 该协议与标准诊断策略类似，不会让患者因数据采集而完全面临风险。 4）研究者团队实力雄厚，之前在PE领域合作研究取得成功。