HBV, HCV, CMV & HHV-8 IN HIV POSITIVE WOMEN IN THAILAND

描述：(摘自摘要)哈佛大学公共卫生学院 泰国研究(PHPT)和泰国最近的围产期艾滋病毒预防试验 建立国家艾滋病疫苗开发数据中心(NDCAVD)，地址： Mahidol大学人口与社会研究所将 努力加强泰国在数据领域的研究能力 在临床试验范围内的管理和统计。具体的 这项建议的目的是调查四种病毒的流行病学 感染--乙肝(乙肝)、丙型肝炎(丙型肝炎)、巨细胞病毒(CMV)和 人类疱疹病毒-8(HHV-8)--与艾滋病毒有关的一大代表 泰国怀孕妇女的样本。这些病毒是为他们的公众选择的 健康重要性或其与艾滋病毒的理论/已知联系。本研究 计划：1)确定每种感染的血清阳性率和相关风险 艾滋病毒阳性和艾滋病毒孕妇的因素；2)决定传播率 这些病毒和在HIV+女性中传播的危险因素 母乳喂养；3)探讨围产期HIV传播与 这些其他病毒；以及4)确定这些病毒的混合感染是否 母亲和儿童艾滋病毒疾病进展的预后危险因素。 在PHPT内对35,000名妇女进行艾滋病毒筛查的血清可用于 测试。所有艾滋病毒阳性妇女，以及随机选择的一组 艾滋病毒阴性(按城市/农村居住地和年龄分层)将进行筛查 这四种病毒。所有婴儿出生时同时感染(艾滋病毒和另一种病毒) 母亲们也将接受相应的病毒检测。社会人口学和 所有妇女的行为数据，婴儿的艾滋病毒状况和进展 来自艾滋病毒感染儿童的数据可从PHPT获得。NDCAVD将 执行所有必要的数据管理并协作进行分析和 释义。作为一个回溯性的子研究，该项目将提供 NDCAVD研究人员在临床数据管理方面的适当培训 试验，以及回答一些重要的问题有关的关联 这些病毒与艾滋病毒和围产期传播有关。

DESCRIPTION: (adapted from abstract) The Harvard School of Public Health's Perinatal HIV Prevention Trial, Thailand study (PHPT) and Thailand's recently established National Data Center for AIDS Vaccine Development (NDCAVD) at Mahidol University's Institute for Population and Social Research have combined efforts to strengthen Thailand's research capacity in the areas of data management and statistics within the context of clinical trials. The specific aims of this proposal are to investigate the epidemiology of four viral infections -- Hepatitis B (HBV), Hepatitis C (HCV), Cytomegalovirus (CMV), and Human Herpes Virus-8 (HHV-8) -- in relation to HIV among a large representative sample of pregnant Thai women. These viruses were chosen for their public health importance or their theoretical/known associations with HIV. This study plans to: 1) determine the seroprevalence of each infection and associated risk factors in HIV+ and HIV- pregnant women; 2) determine the rates of transmission of these viruses and risk factors for transmission in HIV+ women who are not breast feeding; 3) explore the relationship of perinatal HIV transmission to these other viruses; and 4) determine whether co-infection by these viruses are prognostic risk factors for progression of HIV disease in mothers and children. The sera from 35,000 women screened for HIV within the PHPT are available for testing. All HIV-positive women, as well as a randomly selected group of HIV-negative (stratified by urban/rural residence and age), will be screened for these four viruses. All infants born to co-infected (HIV and another virus) mothers will also be tested for the corresponding virus. Sociodemographic and behavioral data from all women, the HIV status of the infants and progression data from HIV-infected children are available from the PHPT. NDCAVD will perform all necessary data management and collaborate in the analysis and interpretation. As a retrospective substudy, this project will provide appropriate training for NDCAVD researchers in the data management of clinical trials, as well as answer some important questions regarding the association of these viruses with HIV and perinatal transmission.