TOTAL SYNTHESIS OF CP-263, 114 AND CP-225, 917
TOTAL SYNTHESIS OF CP-263, 114 AND CP-225, 917
批准号:
6137619
负责人:
GARY ALLEN SULIKOWSKI
金额:
$14.85万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1999
资助国家:
美国
项目状态:
已结题
起止时间:
1999-01-01 至 2001-12-31
中文摘要
两个结构独特的化合物,CP-263,114和CP-225,917
英文摘要
Two structurally unique compounds, CP-263,114 and CP-225,917, were
recently isolated from an unidentified fungus while screening for
squalene synthase inhibitors. These natural products were found to
inhibit ras farnesyl transferase. One objective of this grant
application is to develop a practical and efficient total synthesis of
CP-263,114 and CP-225,917 which will allow the production of modified
versions of these inhibitors for evaluation against ras farnesyl
transferase and squalene synthase.
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科研奖励(0)
会议论文
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项目类别:
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资助金额:$28.92万
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财政年份:2015
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负责人:GARY ALLEN SULIKOWSKI
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依托单位:
Chemistry and Biology of Novel Arachidonic Acid Metabolites
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批准号:9257449
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资助金额:$28.83万
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财政年份:2015
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依托单位:
Chemistry and Biology of Novel Arachidonic Acid Metabolites
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批准号:9100884
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资助金额:$28.87万
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财政年份:2015
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依托单位:
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批准号:7340231
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财政年份:2004
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批准号:6998859
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资助金额:$23.59万
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财政年份:2004
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财政年份:2004
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批准号:6720884
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项目类别:
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资助金额:$11.95万
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财政年份:2004
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财政年份:2002
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依托单位:
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财政年份:2002
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依托单位:
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依托单位:
海外基金