TOTAL SYNTHESIS OF CP-263, 114 AND CP-225, 917
TOTAL SYNTHESIS OF CP-263, 114 AND CP-225, 917
批准号:
6137619
负责人:
GARY ALLEN SULIKOWSKI
金额:
$14.85万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1999
资助国家:
美国
项目状态:
已结题
起止时间:
1999-01-01 至 2001-12-31
中文摘要
2个结构独特的化合物,CP-263,114和CP-225,917,
最近从一种不明真菌中分离出来,当时正在筛选
角鲨烯合成酶抑制剂。这些天然产品被发现
抑制ras法尼基转移酶。这笔赠款的一个目标是
应用是开发一种实用高效的全合成方法
CP-263,114和CP-225,917将允许生产改性
这些抑制剂的版本用于评估对ras法尼基的作用
转移酶和角鲨烯合酶。
英文摘要
Two structurally unique compounds, CP-263,114 and CP-225,917, were
recently isolated from an unidentified fungus while screening for
squalene synthase inhibitors. These natural products were found to
inhibit ras farnesyl transferase. One objective of this grant
application is to develop a practical and efficient total synthesis of
CP-263,114 and CP-225,917 which will allow the production of modified
versions of these inhibitors for evaluation against ras farnesyl
transferase and squalene synthase.
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会议论文
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海外基金