TOTAL SYNTHESIS OF CP-263, 114 AND CP-225, 917

CP-263、114 和 CP-225、917 的全合成

• 批准号: 6137619
• 负责人: GARY ALLEN SULIKOWSKI
• 金额: $ 14.85万
• 依托单位: TEXAS A&M UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-01-01 至 2001-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6137619
• 关键词: Fungi; alkyltransferase; biological products; chemical addition; cyclization; drug design /synthesis /production; enzyme inhibitors; farnesyl compound; heterocyclic compounds; squalene

Two structurally unique compounds, CP-263,114 and CP-225,917, were recently isolated from an unidentified fungus while screening for squalene synthase inhibitors. These natural products were found to inhibit ras farnesyl transferase. One objective of this grant application is to develop a practical and efficient total synthesis of CP-263,114 and CP-225,917 which will allow the production of modified versions of these inhibitors for evaluation against ras farnesyl transferase and squalene synthase.

两种结构独特的化合物CP-263，114和CP-225，917， 最近从一种不明真菌中分离出来， 角鲨烯合酶抑制剂。 这些天然产物被发现 抑制Ras法尼基转移酶。 这笔赠款的一个目的是 应用是开发一个实用和有效的全合成， CP-263，114和CP-225，917，这将允许生产改性的 这些抑制剂用于评估抗Ras法呢基的形式 转移酶和角鲨烯合酶。