The Whitehall II study: A core resource for ageing research

Whitehall II 研究：老龄化研究的核心资源

• 批准号: MR/Y014154/1
• 负责人: Mika Kivimaki
• 金额: $ 63.56万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FY014154%2F1
• 关键词: Whitehall; II; study; core; resource

High quality and reproducibility in science cannot be achieved without a robust study design and high-quality data. The 37-year follow-up of 10,308 Whitehall participants from early midlife to old age with 8 clinical examinations, linked electronic health data and a biorepository which includes over 360,000 stored blood, urine, and hair samples is a unique resource for studying ageing and factors that affect the development and progression of chronic conditions, such as Alzheimer's disease and other dementias, cardiometabolic diseases, and multimorbidity. To maximise the potential of Whitehall as a source of scientific discovery and replication and in accordance with recommendations from the MRC, we propose a cost-effective infrastructure that consists of an accessible biorepository and continued update of health outcomes of Whitehall participants via linkage to health records. Accordingly, we seek MRC funding for costs arising from biosample storage, data extraction services from national registers, and employment of staff to maintain the bioresource, facilitate biosample/data selection and transfers to collaborators; to update and process linked electronic health record data; to manage data sharing with the wider research community ensuring research governance requirements are met; and to curate new data for release to Dementia Platform UK ensuring that the most updated data and derived variables are fully documented and deidentified prior to release. As recommended by the MRC, this proposal does not request support for data analysis or further clinical examinations.With continued infrastructure support, Whitehall resource will uniquely contribute to research aimed at understanding healthy ageing and age-related conditions, and continue to inform prevention, clinical guidelines and policy.

如果没有强有力的研究设计和高质量的数据，科学上的高质量和重复性是不可能实现的。白厅对10,308名参与者从中年早期到老年进行了长达37年的跟踪调查，包括8次临床检查、相关的电子健康数据和一个包含超过360,000份储存的血液、尿液和头发样本的生物库，是研究衰老和影响慢性疾病发展和进展的因素的独特资源，如阿尔茨海默氏症和其他痴呆、心脏代谢性疾病和多发病。为了最大限度地发挥白厅作为科学发现和复制来源的潜力，并根据MRC的建议，我们提出了一个具有成本效益的基础设施，其中包括一个可访问的生物库，以及通过与健康记录的链接来持续更新白厅参与者的健康结果。因此，我们寻求MRC资金，用于生物样本存储、国家登记册的数据提取服务，以及雇用工作人员维护生物资源，促进生物样本/数据选择和传输给合作者；更新和处理链接的电子健康记录数据；管理与更广泛的研究社区的数据共享，确保满足研究治理要求；并整理新数据，发布给英国痴呆症平台，确保在发布之前充分记录最新数据和衍生变量，并确定其身份。根据MRC的建议，这项建议不要求对数据分析或进一步的临床检查提供支持。在持续的基础设施支持下，白厅资源将独特地促进旨在了解健康老龄化和与年龄相关的状况的研究，并继续为预防、临床指南和政策提供信息。