NeuroMAP Phase II - Recruitment and Assessment Core

项目摘要：招聘和评估核心 精神病学研究依赖于使用有效和可靠的自我报告，基于访谈和行为 诊断DSM-5精神障碍的评估，估计精神健康症状的严重程度， 并描绘跨疾病相关的跨诊断结构。招聘与考核 基于神经科学的心理健康评估和预测中心（NeuroMAP） II将支持研究项目负责人（RPL）和试点项目调查员（PPI）， 完成招募、筛选和共同核心面试，自我报告和行为 评估程序。招聘和评估核心的目标是加快RPL， 通过允许有效的参与者招募和更快速的数据收集， 根据核心数据制定目标和假设，从而使R级赠款申请更多 竞争择优的科学化招聘和评估核心将与电路和分子核心密切合作 支持多层次的评估方法（症状和行为，电路和生理，细胞和 分子），并被构造为支持NeuroMAP主题：通过 实验方法，有针对性的疾病修饰过程（DMPs）的情绪和焦虑症。 在第一阶段，所有过往资历认可计划均已建立共通数据元素， 个别过往资历认可计划的研究目标与生产者物价指数的二手数据分析之间的关系。在此 在第一阶段，核心项目招募了552名RPL参与者，每个项目都达到了招募目标 尽管SARS-CoV-2和研究所关闭了两个月，但仍取得了里程碑式的进展。此外，8 PPI使用了核心 数据，以确定新的DMPs在情绪和焦虑症。该核心侧重于从一个 修改的NIMH研究领域标准方法：（a）负价系统测量，即，如何 个人对令人厌恶的情况或背景做出反应（RPL项目1侧重于威胁敏感性;项目2 项目3侧重于重复性消极思维）;（B）积极效价 系统措施，即，个人如何对积极的激励情境或背景做出反应（项目2将 （c）内感受测量，即感知、处理和整合内部感受， 身体信号与外部刺激一起影响动机行为（项目2侧重于对 内感受扰动）。核心的目标是（1）提供及时的征聘和标准化的 所有NeuroMAP项目的评估;（2）保持可重复和可靠的评估结构 可用于校外支持的项目;（3）制定自我可持续的业务计划， 用户基础。核心将是LIBR研究人员以及其他研究人员的独特资源。 俄克拉荷马州和阿肯色州东北部的学术机构。

PROJECT SUMMARY: Recruitment and Assessment Core Psychiatric research relies on the use of validated and reliable self-report, interview-based, and behavioral assessments to diagnose DSM-5 psychiatric disorders, estimate level of severity of mental health symptoms, and to delineate transdiagnostic constructs of relevance across disorders. The Recruitment and Assessment Core of the Center for Neuroscience-based Mental Health Assessment and Prediction (NeuroMAP) in Phase II will support Research Project Leaders (RPLs) and Pilot Project Investigators (PPIs) by overseeing and completing the recruitment, screening, and common Core interview-based, self-report, and behavioral assessment procedures. The goal of the Recruitment and Assessment Core is to accelerate the RPL and PPI projects by allowing for efficient participant recruitment and more rapid data collection, aiding in the formulation of aims and hypotheses based on core data, and thereby making R-level grant applications more competitive. The Recruitment and Assessment Core will work closely with the Circuits and Molecules Core to support a multi-level assessment approach (symptoms & behavior, circuits & physiology, cells & molecules) and is structured to support the NeuroMAP theme: identification and validation, via an experimental approach, of targetable disease-modifying processes (DMPs) in mood and anxiety disorders. During Phase I, common data elements were established across all RPL projects and provided a balance between the research goals of the individual RPL projects and secondary data analyses for PPIs. During this phase, the Core was able to recruit 552 participants for RPLs and each project reached recruitment milestones despite SARS-CoV-2 and a two-month shutdown of the institute. Moreover, 8 PPI used the Core data to identify novel DMPs in mood and anxiety disorders. The Core focuses on measures derived from a modified NIMH Research Domain Criteria approach: (a) Negative Valence Systems measures, i.e., how individuals respond to aversive situations or context (RPL Project 1 focuses on threat sensitivity; Project 2 focuses on avoidance behavior, Project 3 focuses on repetitive negative thinking); (b) Positive Valence Systems measures, i.e., how individuals respond to positive motivational situations or contexts (Project 2 will focus on approach motivation); (c) Interoception measures, i.e. sensing, processing, and integrating internal bodily signals together with external stimuli to affect motivated behavior (Project 2 focuses on responses to interoceptive perturbation). The aims of the core are (1) to provide timely recruitment and standardized assessments for all NeuroMAP projects; (2) to maintain a reproducible and reliable assessment structure that can be used for extramurally supported projects; and (3) to develop a self-sustainable business plan for the user base. The Core will be a unique resource for LIBR investigators as well as researchers at other academic institutions in northeastern Oklahoma and Arkansas.