NeuroMAP Phase II - Recruitment and Assessment Core

NeuroMAP 第二阶段 - 招募和评估核心

• 批准号: 10711136
• 负责人: ROBIN L AUPPERLE
• 金额: $ 33.99万
• 依托单位: LAUREATE INSTITUTE FOR BRAIN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10711136
• 关键词: 2019-nCoV; Acceleration; Accounting; Address; Adult; Affect; Anxiety Disorders; Applications Grants; Arkansas; Behavior; Behavior assessment; Businesses; Cells; Cities; Common Core; Common Data Element; DSM-V; Data; Data Analyses; Data Collection; Databases; Development; Diagnosis; Diagnostic; Disease; Equilibrium; Extramural Activities; Fee-for-Service Plans; Formulation; Future; Goals; Guidelines; Health Sciences; Individual; Infrastructure; Institution; Interoception; Interview; Leadership; Literature; Measures; Mental Health; Mental disorders; Mood Disorders; Moods; Motivation; National Institute of Mental Health; Negative Valence; Neurosciences; Neurosciences Research; Oklahoma; Participant; Patient Recruitments; Patient Self-Report; Performance; Phase; PhenX Toolkit; Physiology; Pilot Projects; Positive Valence; Procedures; Process; Reproducibility; Research; Research Domain Criteria; Research Personnel; Research Project Grants; Research Support; Resources; Severities; Signal Transduction; Standardization; Stimulus; Structure; Symptoms; System; Teenagers; Thinking; Training; United States National Institutes of Health; Universities; Update; Validation; Work; approach behavior; avoidance behavior; base; health assessment; instrument; meetings; motivated behavior; negative affect; novel; operation; recruit; research study; response; screening

PROJECT SUMMARY: Recruitment and Assessment Core Psychiatric research relies on the use of validated and reliable self-report, interview-based, and behavioral assessments to diagnose DSM-5 psychiatric disorders, estimate level of severity of mental health symptoms, and to delineate transdiagnostic constructs of relevance across disorders. The Recruitment and Assessment Core of the Center for Neuroscience-based Mental Health Assessment and Prediction (NeuroMAP) in Phase II will support Research Project Leaders (RPLs) and Pilot Project Investigators (PPIs) by overseeing and completing the recruitment, screening, and common Core interview-based, self-report, and behavioral assessment procedures. The goal of the Recruitment and Assessment Core is to accelerate the RPL and PPI projects by allowing for efficient participant recruitment and more rapid data collection, aiding in the formulation of aims and hypotheses based on core data, and thereby making R-level grant applications more competitive. The Recruitment and Assessment Core will work closely with the Circuits and Molecules Core to support a multi-level assessment approach (symptoms & behavior, circuits & physiology, cells & molecules) and is structured to support the NeuroMAP theme: identification and validation, via an experimental approach, of targetable disease-modifying processes (DMPs) in mood and anxiety disorders. During Phase I, common data elements were established across all RPL projects and provided a balance between the research goals of the individual RPL projects and secondary data analyses for PPIs. During this phase, the Core was able to recruit 552 participants for RPLs and each project reached recruitment milestones despite SARS-CoV-2 and a two-month shutdown of the institute. Moreover, 8 PPI used the Core data to identify novel DMPs in mood and anxiety disorders. The Core focuses on measures derived from a modified NIMH Research Domain Criteria approach: (a) Negative Valence Systems measures, i.e., how individuals respond to aversive situations or context (RPL Project 1 focuses on threat sensitivity; Project 2 focuses on avoidance behavior, Project 3 focuses on repetitive negative thinking); (b) Positive Valence Systems measures, i.e., how individuals respond to positive motivational situations or contexts (Project 2 will focus on approach motivation); (c) Interoception measures, i.e. sensing, processing, and integrating internal bodily signals together with external stimuli to affect motivated behavior (Project 2 focuses on responses to interoceptive perturbation). The aims of the core are (1) to provide timely recruitment and standardized assessments for all NeuroMAP projects; (2) to maintain a reproducible and reliable assessment structure that can be used for extramurally supported projects; and (3) to develop a self-sustainable business plan for the user base. The Core will be a unique resource for LIBR investigators as well as researchers at other academic institutions in northeastern Oklahoma and Arkansas.

项目摘要：招聘和评估核心 精神病研究依赖于使用经过验证和可靠的自我报告，基于面试和行为的使用 评估以诊断DSM-5精神疾病，心理健康症状严重程度的估计水平， 并描绘跨疾病相关性的转诊构建体。招聘和评估 基于神经科学的心理健康评估与预测中心（NEUROMAP）的核心 II将通过监督和 完成招聘，筛选和基于核心面试的招聘，自我报告和行为 评估程序。招聘和评估核心的目标是加速RPL和 PPI项目通过允许有效的参与者招聘和更快速的数据收集，以帮助 基于核心数据的目标和假设的提出，从而使R级赠款应用程序更多 竞争的。招聘和评估核心将与电路和分子核心紧密合作 支持多层次评估方法（症状与行为，电路和生理学，细胞和 分子）并结构为支持神经图主题：识别和验证，通过 实验方法，情绪和焦虑症的可定位疾病改良过程（DMP）。 在第一阶段，在所有RPL项目中都建立了共同的数据元素，并提供了平衡 在单个RPL项目的研究目标与PPI的辅助数据分析之间。在此期间 阶段，核心能够招募552名参与者进行RPL，每个项目都招募了 尽管SARS-COV-2和研究所关闭了两个月，但里程碑。此外，8 ppi使用了核心 数据以识别情绪和焦虑症的新型DMP。核心重点是从 修改的NIMH研究领域标准方法：（a）负价系统测量，即如何 个人应对厌恶情况或环境（RPL项目1的重点介绍威胁敏感性；项目2 专注于回避行为，项目3专注于重复的负面思维）； （b）正价 系统措施，即个人如何应对积极的动机情况或环境（项目2将 专注于方法动机）； （c）跨感受度量，即感测，处理和整合 身体信号以及外部刺激以影响动机行为（项目2侧重于对 感受性扰动）。核心的目的是（1）提供及时的招聘和标准化 评估所有神经图项目； （2）保持可再现可靠的评估结构 可用于外部支持的项目； （3）制定一个自我维持的商业计划 用户群。核心将是图书馆调查人员以及其他研究人员的独特资源 俄克拉荷马州东北部和阿肯色州的学术机构。