Adult Determinants of Late Life Depression, Cognitive Decline and Physical Functioning - The Whitehall II Ageing Study

晚年抑郁、认知衰退和身体机能的成人决定因素 - Whitehall II 老龄化研究

• 批准号: MR/K013351/1
• 负责人: Mika Kivimaki
• 金额: $ 443.43万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FK013351%2F1
• 关键词: Adult; Determinants; Late; Life; Depression

The number of older adults with mental health problems, such as depression and dementia, is rapidly increasing. In 15 years time, over 4.3 million people in the UK will be affected. Together with physical limitations, this escalating burden of age-related disability will have a profound impact on the capacity for independent living, as well as major social and health care implications. The voluminous and informative research into age-related disability has largely focused on determinants measured in old age. In order to better separate cause and effect, and to identify novel targets for intervention before the onset of age-related disability, we propose to study risk factors and functioning from mid-life to old-age in the Whitehall II (WII) cohort. WII is perfectly placed for this research as the study has collected an array of data across the adult life course on a cohort of 10,308 London-based civil servants recruited in 1985. Our proposed programme of work includes the collection of a new wave of clinical data (clinic 7) to cover the age range of 65-85 and to extend the wealth of information already available from the WII cohort. There is a striking overlap between the risk factors for late-life depression and the decline in cognitive and physical functioning. This may be due to shared causal pathologies and/or shared lifestyle, social and behavioural factors. The proposed programme examines these issues within a single, cohesive analytic framework. The assets for discovery in WII include data on a wider range of adulthood risk factors than any other large-scale UK cohort study. These have been measured repeatedly at regular 4-5 year intervals since 1985. Another major advantage is the high-resolution measurements of depressive and anxiety symptoms, cognitive and physical functioning. The proposal requests resources for a combination of infrastructure (core funding for data collection) and research over the period 2013-2017. Our objectives cover various domains of midlife risk and protective factors for old-age mental health and functioning. Using 30 years of prospective follow-up, we will examine the role of socioeconomic status, social engagement and cognitive reserve as contextual influences ('the causes of the causes') and quantify the importance of lifestyle factors, with attention to the role of changes in health behaviours. We hypothesise that mid-life trajectories of inflammatory, vascular, and metabolic factors will make a major contribution to later life depression, cognitive impairment, and functional health. Findings from WII will be replicated using other large-scale studies. We will then translate any observed effects into impact on the prevalence of functional limitations and disability-free life expectancy using projected risk factor distributions in the general population. This programme will contribute to public health policy, health and social care, and will have societal impacts. With effective data-sharing policies already in place, the new data will contribute to the wider scientific community advancing gerontological, neuroscientific, medical, psychological, epidemiological and genetic research, including cross-sector collaborative ventures. Our active research collaboration with universities and research institutes in the UK and abroad enable capacity building for future researchers in the field.

患有抑郁症和痴呆症等精神健康问题的老年人人数正在迅速增加。15年后，英国将有超过430万人受到影响。与年龄有关的残疾加上身体上的限制，将对独立生活的能力产生深远影响，并对社会和保健产生重大影响。 对与年龄有关的残疾问题进行的大量翔实的研究主要侧重于在老年时衡量的决定因素。为了更好地分离原因和影响，并确定新的目标，在年龄相关的残疾发生前进行干预，我们建议研究风险因素和功能，从中年到老年的白厅II（WII）队列。WII非常适合这项研究，因为该研究收集了1985年招募的10，308名伦敦公务员的成年生活过程中的一系列数据。我们拟议的工作方案包括收集新一波的临床数据（诊所7），以涵盖65-85岁的年龄范围，并扩大WII队列中已有的丰富信息。 晚年抑郁症的风险因素与认知和身体功能下降之间存在惊人的重叠。这可能是由于共同的因果病理和/或共同的生活方式，社会和行为因素。拟议的方案在一个统一的分析框架内审查这些问题。WII的发现资产包括比任何其他大规模英国队列研究更广泛的成年风险因素的数据。自1985年以来，每隔4-5年定期重复测量这些数据。另一个主要优势是对抑郁和焦虑症状、认知和身体功能的高分辨率测量。 该提案要求在2013-2017年期间为基础设施（数据收集核心资金）和研究提供资源。我们的目标涵盖中年风险和老年心理健康和功能保护因素的各个领域。通过30年的前瞻性随访，我们将研究社会经济地位、社会参与和认知储备作为背景影响（“原因的原因”）的作用，并量化生活方式因素的重要性，同时关注健康行为变化的作用。我们假设，中年的炎症，血管和代谢因素的轨迹将作出重大贡献，晚年抑郁症，认知障碍和功能健康。WII的研究结果将使用其他大规模研究进行复制。然后，我们将使用预测的风险因素分布在一般人群中将任何观察到的影响转化为对功能限制和无残疾预期寿命的影响。 该计划将有助于公共卫生政策、健康和社会关怀，并将产生社会影响。由于有效的数据共享政策已经到位，新数据将有助于更广泛的科学界推进老年学、神经科学、医学、心理学、流行病学和遗传学研究，包括跨部门合作企业。我们与英国和国外的大学和研究机构积极开展研究合作，为该领域未来的研究人员提供能力建设。

项目成果

Tinned fruit consumption and mortality in three prospective cohorts.

• DOI: 10.1371/journal.pone.0117796
• 发表时间: 2015
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Aasheim ET;Sharp SJ;Appleby PN;Shipley MJ;Lentjes MA;Khaw KT;Brunner E;Key TJ;Wareham NJ
• 通讯作者: Wareham NJ

Assessing cortisol from hair samples in a large observational cohort: The Whitehall II study.

• DOI: 10.1016/j.psyneuen.2016.07.214
• 发表时间: 2016-11
• 期刊: PSYCHONEUROENDOCRINOLOGY
• 影响因子: 3.7
• 作者: Abell, Jessica G.;Stalder, Tobias;Ferrie, Jane E.;Shipley, Martin J.;Kirschbaum, Clemens;Kivimaki, Mika;Kumari, Meena
• 通讯作者: Kumari, Meena

Prediction of violence or threat of violence among employees in social work, healthcare and education: the Finnish Public Sector cohort study.

社会工作，医疗保健和教育中员工中暴力或暴力威胁的预测：芬兰公共部门队列研究。

• DOI: 10.1136/bmjopen-2023-075489
• 发表时间: 2023-08-29
• 期刊: BMJ OPEN
• 影响因子: 2.9
• 作者: Airaksinen, Jaakko;Pentti, Jaana;Seppala, Piia;Virtanen, Marianna;Ropponen, Annina;Elovainio, Marko;Kivimaki, Mika;Ervasti, Jenni
• 通讯作者: Ervasti, Jenni

Physical Activity, Sedentary Behavior, and Long-Term Changes in Aortic Stiffness: The Whitehall II Study.

• DOI: 10.1161/jaha.117.005974
• 发表时间: 2017-08-07
• 期刊: Journal of the American Heart Association
• 影响因子: 5.4
• 作者: Ahmadi-Abhari S;Sabia S;Shipley MJ;Kivimäki M;Singh-Manoux A;Tabak A;McEniery C;Wilkinson IB;Brunner EJ
• 通讯作者: Brunner EJ

Raised blood pressure and risk of dementia: our response.

血压升高和痴呆风险：我们的应对措施。

• DOI: 10.1093/eurheartj/ehy917
• 发表时间: 2019
• 期刊: European heart journal
• 影响因子: 39.3
• 作者: Abell JG