ADAPTIVE FUNCTIONAL MRI

描述(逐字摘自申请者摘要)：本报告的目的 项目是开发一种新的方法，自适应功能磁共振 成像(MR)，实现人脑的精确空间定位 功能。这种方法的预期应用是术前计划。 以及术中神经外科干预的指导。临床部 这项工作的意义在于它将创造一种新的工具来最小化 手术后患者的功能缺陷。假设是 动态自适应核磁共振可以在 1.5 mm各向同性分辨率，同时仍保持临床实用成像 不到15分钟的时间。检验这一假设的具体目标是： (1)开发既适用于功能磁共振又适用于功能磁共振的成像序列 符合动态自适应磁共振成像的要求；(2)开发 实时协议，以实现必要的计算机-扫描仪交互 满足动态自适应成像要求；(3)软件开发 用于在动态自适应中实时处理和显示功能磁共振数据 (4)基于A/S的动态自适应核磁共振成像算法 多分辨率变焦方法；(5)多分辨率优化 自适应功能磁共振成像方法及其相对于常规方法的性能评估 FMRI；以及(6)将动态自适应fMRI应用于神经外科计划 并根据其本地化的精确度和准确性对其进行评估 功能。实时自适应成像是一种修改图像的方法 随着审查的进行，采购战略“在线”，以便为其量身定做 到每个单独的大脑，然后放大局部的激活部位。这个 该项目的长期目标是充分发展这一方法，以便 为外科医生提供多功能和强大的技术工具 (包括新的方法、硬件和软件)以加强规划， 指导和监测神经外科干预措施。

DESCRIPTION (Verbatim from the Applicant's Abstract): The objective of this project is to develop a new method, adaptive functional magnetic resonance imaging (MR), to enable the precise spatial localization of human brain function. The intended application of this method is the preoperative planning and intraoperative guidance of neurosurgical interventions. The clinical significance of this work is that it will create a new instrument to minimize post-operative functional deficits for surgical patients. The hypothesis is that dynamically adaptive MRI can perform whole-brain functional mapping at 1.5mm isotropic resolution while still maintaining clinically practical imaging times of less than 15 minutes. The specific aims to test this hypothesis are: (1) To develop imaging sequences that are both suitable for functional MRI and compatible with the requirements of dynamically adaptive MRI; (2) To develop real-time protocols to enable the necessary computer-scanner interaction to meet the requirements of dynamically adaptive imaging; (3) To develop software for real-time processing and display of fMRI data in a dynamically adaptive environment; (4) To develop algorithms for dynamically adaptive MRI based on a multi-resolution zooming approach; (5) To optimize the multi-resolution adaptive fMRI method and to evaluate performance with respect to conventional fMRI; and (6) To apply dynamically adaptive fMRI for neurosurgical planning and, to evaluate it with respect to its precision and accuracy for localizing function. Real-time adaptive imaging is a methodology that modifies the image acquisition strategy "on-line" as an examination proceeds in order to tailor it to each individual brain and then zoom-in on local sites of activation. The long-term goal of this project is to fully develop this methodology in order to provide the surgeon with a versatile and powerful technological tool (comprising new methods, hardware and software) to enhance the planning, guiding and monitoring of neurosurgical interventions.