IMAGING METHODS FOR IMAGE GUIDED THERAPY

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。该项目的总体目标是利用射频激励和射频灵敏度曲线的灵活性开发混合成像序列，并使这些方法可作为增强MRI引导治疗应用的资源，特别是基于MRI的热疗法监测。 我们的具体目标是实现这一目标：（1）开发混合成像序列的图像引导治疗结合非傅立叶和RF编码与标准傅立叶编码的MRI方法。(2)开发运动鲁棒的、具有多种对比度的单次激发自旋回波线扫描和板扫描序列用于图像引导治疗。（3）开发适合图像引导治疗需要的各种并行成像实现。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The general goal of this project is to exploit the flexibility of RF excitation and RF sensitivity profiles for the development of hybrid imaging sequences and, to make these methods available as a resource for enhancing MRI-guided therapy applications, in particular, MRI-based monitoring of thermal therapies. Our specific aims to achieve this goal are: (1) To develop hybrid imaging sequences for image-guided therapy combining non-Fourier and RF encoding with standard Fourier-encoded MRI methods. (2) To develop motion-robust, single-shot spin-echo line-scan and slab-scan sequences with multiple contrasts for image-guided therapy, (3) To develop a variety of parallel imaging implementations tailored to the needs of image-guided therapy.